The Impact of Volume on Related Cell Counts Using The MARROW CELLUTION™ Bone Marrow Aspiration System
Michael A. Scarpone, Daniel Kuebler.
Pilot Study | White Paper
Michael A. Scarpone, D.O. and Dr. Daniel Kuebler investigated if reducing the Marrow Cellution aspiration volume per location would lead to higher stem-/progenitor cell concentrations.
The key findings of their study are:
- Improved Cell Concentrations: Reducing the aspiration volume per site from 1 ml to 0.5 ml using the Marrow Cellution (MC) device significantly improved the concentrations of stem and progenitor cells.
- Comparable CFU-f Values: The CFU-f values obtained with the MC system were comparable to those typically found in autograft bone.
- Minimal Morbidity: The MC system requires only a single insertion point, minimizing morbidity compared to traditional methods.
- Retention of All Cells and Growth Factors: The MC aspirate is not filtered or manipulated, preserving all cells and growth factors.
- Potential as an Autograft Substitute: The results suggest that the MC system can be effectively combined with an appropriate carrier to serve as a substitute for autograft.
These findings indicate that the MC system is a promising method for obtaining highly concentrated stem and progenitor cells with minimal morbidity.
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The Marrow Cellution™ System is designed to minimize and eliminate the restrictive limitations associated with “point of care” processing systems which employ inefficient traditional aspiration trocar technology and are regulated as drugs “Advanced Therapies Medicinal Products (ATMP)”. Marrow Cellution™ is a minimally invasive bone/cell enriched autograft access and retrieval system, which does not require additional manipulation or processing, it never leaves the sterile field and provides rich autograft without associated morbidity.
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