Platelet-Rich Plasma Library

The tables below show randomized controlled trials that used Platelet-Rich Plasma (PRP) to treat various indications sorted by publication year. Only studies that are listed in the US National Library of Medicine (PubMed) were included. We try to add the latest and most actual trials only. However, the tables are just an overview and do not claim to be complete.

Click on the green “+” button in the first column of a trial to view more information and trial conclusion.

PRP Injection Therapy in Orthopedics

PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Effectiveness of single intra-bursal injection of platelet-rich plasma against corticosteroid under ultrasonography guidance for shoulder impingement syndrome: a randomized clinical trial.Hewavithana PB, et al.Corticosteroid601 yrPRP and triamcinolone in the SASD bursa could be considered as safe treatment options for SIS under ultrasonography guidance. While triamcinolone was effective in short-term pain reduction, PRP was effective in long-term improvement in shoulder abduction.Shoulder Impingement Syndrome (SIS)RandomizedSkeletal Radiol.2024
Comparing the Efficacy of Intra-articular Platelet-Rich Plasma and Corticosteroid Injections in the Management of Frozen Shoulder: A Randomized Controlled TrialSomisetty TK, et al.Corticosteroid6824 wksOur findings suggest that IA PRP injections provide better long-term results than IA CS injections for managing FS. Platelet-rich plasma can be used as a treatment modality for better outcomes, particularly when the patient is contraindicated or refuses CS treatment. Further research is needed to evaluate the efficacy of these treatment modalities at different stages of FS and explore the potential benefits of ultrasound-guided injections.Adhesive CapsulitisRandomizedCureus.2023
Effects of Platelet-Rich Plasma in Tear Size Reduction in Partial-Thickness Tear of the Supraspinatus Tendon Compared to Corticosteroids InjectionTanpowpong T, et al.Corticosteroid296 mthsIntralesional PRP injection can reduce the tear size in partial-thickness tears of the supraspinatus tendon. Subacromial steroid injection did not significantly affect the tear size. While CS improved functional scores compared with baseline, PRP resulted in better improvement 6 months post-injection.Rotator Cuff TearRandomizedSports Med Open.2023
Comparison of the Efficacy of Platelet-Rich Plasma (PRP) and Local Corticosteroid Injection in Periarthritis Shoulder: A Prospective, Randomized, Open, Blinded End-Point (PROBE) StudyGupta GK, et al.Corticosteroid6024 wksThe triamcinolone group showed better short-term outcomes whereas PRP showed better long-term outcomes in reducing pain and disability scores in terms of VAS and DASH scores.Adhesive CapsulitisRandomizedCureus.2022
Efficacy of Ultrasound-Guided Glenohumeral Joint Injections of Leukocyte-Poor Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-Blind Controlled TrialKirschner JS, et al.HA7012 mthsThere were no differences in pain and functional outcomes after a single injection of LP-PRP versus HA. However, significant improvements in pain and function were observed after both treatments in patients with glenohumeral osteoarthritis.Osteoarthritis (Shoulder)Randomized, Double-BlindClin J Sport Med.2022
Comparison of Functional Outcome Between Intra-Articular Injection of Corticosteroid Versus Platelet-Rich Plasma in Frozen Shoulder: A Randomized Controlled TrialShahzad HF, et al.Corticosteroid20212 wksIntra-articular injection of PRP resulted in a substantial improvement in the VAS score, UCLA, and ROM when compared to intra-articular corticosteroid injection in patients with FS.Adhesive CapsulitisRandomizedCureus.2021
Comparison of a Platelet-Rich Plasma Injection and a Conventional Steroid Injection for Pain Relief and Functional Improvement of Partial Supraspinatus TearsThepsoparn M, et al.Corticosteroid316 mthsAn injection using either a corticosteroid or LP-PRP resulted in a similar reduction in pain and improvement in function at 1 month in patients with a partial supraspinatus tear. However, PRP showed superior benefits over the corticosteroid at 6-month follow-up.Rotator Cuff TearRandomizedOrthop J Sports Med.2021
Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study.Karabaş Ç, et al.Physical Therapy4012 wksThe addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis.Adhesive CapsulitisRandomizedTurk J Phys Med Rehabil.2021
Comparison of the Effectiveness of Platelet-Rich Plasma, Corticosteroid, and Physical Therapy in Subacromial Impingement SyndromePasin T, et al.Corticosteroid, Phys. Therapy/TENS/US908 wks'All three treatment modalities were effective in the treatment of SAIS. However, we suggest that the inexpensive and noninvasive methods of physical therapy and exercise should be the first preferred treatment in SAIS owing to causing no adverse events.Subacromial Impingement Syndrome (SAIS)RandomizedArch Rheumatol.2019
Efficacy of Platelet-Rich Plasma for the Treatment of Interstitial Supraspinatus Tears: A Double-Blinded, Randomized Controlled Trial.Schwitzguebel AJ, et al.Saline8012 mthsPRP injections within interstitial supraspinatus tears did not improve tendon healing or clinical scores compared with saline injections and were associated with more adverse events.Rotator Cuff TearRandomized, Double-BlindAm J Sports Med.2019
Sodium Hyaluronate and Platelet-Rich Plasma for Partial-Thickness Rotator Cuff Tears.Cai YU, et al.Saline, HA, HA+PRP200 (184 fin.)12 mthsOur study provided evidence of the efficacy of PRP injection in the healing of small to medium PTRCT. Moreover, the combined injection of SH and PRP yielded a better clinical outcome than SH or PRP alone.Rotator Cuff TearRandomizedMed Sci Sports Exerc.2019
Platelet-rich plasma injection in the treatment of frozen shoulder: A randomized controlled trial with 6-month follow-upLin J.Anesthetic606 mthsPRP and procaine were effective in treating frozen shoulder. PRP was more effective and had a more prolonged efficiency than the procaine control. Nevertheless, the definite conclusion should come from further large-scale clinical trials.Adhesive CapsulitisRandomizedInt J Clin Pharmacol Ther.2018
Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled TrialNejati P, et al.Physical Therapy626 mths'Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective.Subacromial Impingement Syndrome (SAIS)RandomizedOrthop J Sports Med.2017
Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tearsShams A, et al.Corticosteroid406 mthsPRP injections showed earlier better results as compared to corticosteroid injections, although statistically significant better results after 6 months could not be found. Therefore, subacromial RPP injection could be considered as a good alternative to corticosteroid injection, especially in patients with a contraindication to corticosteroid administration.Rotator Cuff TearRandomizedEur J Orthop Surg Traumatol.2016
Platelet-Rich Plasma Treatment With Physical Therapy in Chronic Partial Supraspinatus TearsIlhanli I, et al.Physical Therapy7012 mthsWhen we compared with PT, PRP seemed to be a well-tolerated application which showed promising results in patients with chronic partial supraspinatus tears.Rotator Cuff TearRandomizedIran Red Crescent Med J.2015
Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up.Kesikburun S, et al.Saline401 yrAt 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program.Rotator Cuff TearRandomized, Double-BlindAm J Sports Med.2013
Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial.Rha DW, et al.Dry Needling396 mthsAutologous platelet-rich plasma injections lead to a progressive reduction in the pain and disability when compared to dry needling. This benefit is certainly still present at six months after treatment. These findings suggest that treatment with platelet-rich plasma injections is safe and useful for rotator cuff disease.Rotator Cuff DiseaseRandomized, Double-BlindClin Rehabil.2013
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Is Ultrasound (US)-Guided Platelet-Rich Plasma Injection More Efficacious as a Treatment Modality for Lateral Elbow Tendinopathy Than US-Guided Steroid Injection?: A Prospective Triple-Blinded Study with Midterm Follow-up.Kamble P, et al.Corticosteroid642 yearCorticosteroid injections alleviated symptoms of LET over short-term follow-up providing quicker symptomatic relief; however, the effect faded off over the long term. PRP injections provided a more gradual but sustained improvement over the long-term follow-up, indicating the biological healing potential of PRP.EpicondylitisRandomized, Triple-BlindClin Orthop Surg.2023
Management of Lateral Epicondylitis: A Prospective Comparative Study Comparing the Local Infiltrations of Leucocyte Enriched Platelet-Rich Plasma (L-aPRP), Glucocorticoid and Normal SalineArora KK, et al.Corticosteroid, Saline6012 wksPRP leads to superior healing with long-term therapeutic advantages compared to corticosteroids though it takes a little longer to have its effect.EpicondylitisRandomizedMalays Orthop J.2022
Comparison of platelet-rich plasma and extracorporeal shock wave therapy in patients with chronic lateral epicondylitis: A prospective, randomized-controlled study. Şahbaz T, et al.ESW746 mthsIn the treatment of chronic LE, PRP combined with exercise seems to be superior to exercise or ESWT in terms of pain and functionality in chronic LE patients.EpicondylitisRandomizedTurk J Phys Med Rehabil.2021
Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trialMartin JI, et al.Lidocaine7112 mthsPRP results in similar improvements to those obtained with lidocaine. Selecting patients according to their pretreatment status can improve treatment efficacy.EpicondylitisRandomized, Double-BlindJ Orthop Surg Res.2019
Relationship of cytokine levels and clinical effect on platelet-rich plasma-treated lateral epicondylitisLim W, et al.Physical Therapy15624 wksAt 24 weeks, all pain and functional variables, including VAS score, Mayo Clinic performance scores, and MRI grade, improved significantly in group 1 (p < 0.05). PDGF-AB, PDGF-BB, and TGF-β levels were more significantly increased in PRP than in whole blood. TGF-β level significantly correlated with Mayo Clinic performance score and MRI grade improvement. Thus, TGF-β level in PRP is considered to play a pivotal role in tendon healing. These results may contribute to identifying the best protocol for PRP application in tendinopathies.EpicondylitisRandomizedJ Orthop Res.2018
Autologous Platelet-rich Plasma versus Corticosteroid in the Management of Elbow Epicondylitis: A Randomized Study.Varshney A, et al.Corticosteroid836 mthsTreatment of patients with epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection.EpicondylitisRandomizedInt J Appl Basic Med Res.2017
Arthroscopic Debridement Versus Platelet-Rich Plasma Injection: A Prospective, Randomized, Comparative Study of Chronic Lateral Epicondylitis With a Nearly 2-Year Follow-UpMerolla G, et al.Debridement1012 yrs'The present findings suggest that (1) PRP injections and arthroscopic extensor carpi radialis brevis release are both effective in the short and medium term; (2) PRP patients experienced a significant worsening of pain at 2 years; (3) arthroscopic release ensured better long-term outcomes in terms of pain relief and grip strength recovery; and (4) both procedures were safe and well accepted by patients.EpicondylitisRandomizedArthroscopy.2017
Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial.Palacio EP, et al.Neocaine, Glucocorticoid60180 daysAt a significance level of 5%, there was no evidence that one treatment was more effective than another, when assessed using the DASH and PRTEE questionnaires.EpicondylitisRandomizedRev Bras Ortop.2016
[Treatment of elbow epicondylitis with platelet rich plasma versus local corticosteroids]Martínez-Montiel O, et al.Corticosteroid606 mthsThe results show that platelet rich plasma provided better results from the perspective of pain control and effect duration. However, the number of applications and the possibility of improving the outcomes if combined with rehabilitation have not yet been determined.EpicondylitisRandomizedActa Ortop Mex. Spanish.2015
Comparison of Local Injection of Platelet Rich Plasma and Corticosteroids in the Treatment of Lateral Epicondylitis of Humerus.Yadav R, et al.Glucocorticoid653 mthsPRP and methyl-prenisolone both are effective in the treatment of lateral epicondylitis. However, PRP is a superior treatment option for longer duration efficacy.EpicondylitisRandomizedJ Clin Diagn Res.2015
Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation.Gautam VK, et al.Corticosteroid306 mthsPRP appeared to enable biological healing of the lesion, whereas CS appeared to provide short-term, symptomatic relief but resulted in tendon degeneration.EpicondylitisRandomizedJ Orthop Surg (Hong Kong).2015
Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients.Mishra AK, et al.Physical Therapy23024 wksNo significant differences were found at 12 weeks in this study. At 24 weeks, however, clinically meaningful improvements were found in patients treated with leukocyte-enriched PRP compared with an active control group.EpicondylitisRandomized, Double-Blind, Multi-CenterAm J Sports Med.2014
Is Platelet-rich plasma superior to whole blood in the management of chronic tennis elbow: one year randomized clinical trial.Raeissadat SA, et al.Whole Blood7612 mths'PRP and autologous whole blood injections are both effective methods to treat chronic lateral epicondylitis and their efficacy persisted during long term follow up. PRP was not superior to AWB in long term follow up.EpicondylitisRandomizedBMC Sports Sci Med Rehabil.2014
Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial.Krogh TP, et al.Glucocorticoid, Saline603 mthsNeither injection of PRP nor glucocorticoid was superior to saline with regard to pain reduction in LE at the primary end point at 3 months. However, injection of glucocorticoid had a short-term pain-reducing effect at 1 month in contrast to the other therapies. Injection of glucocorticoid in LE reduces both color Doppler activity and tendon thickness compared with PRP and saline.EpicondylitisRandomized, Double-BlindAm J Sports Med.2013
Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up.Gosens T, et al.Corticosteroid1002 yearTreatment of patients with chronic lateral epicondylitis with PRP reduces pain and increases function significantly, exceeding the effect of corticosteroid injection even after a follow-up of 2 years. Future decisions for application of PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits.EpicondylitisRandomized, Double-Blind, Multi-CenterAm J Sports Med.2011
Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial.Thanasas C, et al.Whole Blood286 mthsRegarding pain reduction, PRP treatment seems to be an effective treatment for chronic lateral elbow epicondylitis and superior to autologous blood in the short term. Defining details of indications, best PRP concentration, number and time of injections, as well as rehabilitation protocol might increase the method's effectiveness. Additionally, the possibility of cost reduction of the method might justify the use of PRP over autologous whole blood for chronic or refractory tennis elbow.EpicondylitisRandomizedAm J Sports Med.2011
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
One-Year Efficacy of Platelet-Rich Plasma for Moderate-to-Severe Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled TrialChen SR, et al.Saline26 (52 wrists)12 mthsA single dose of ultrasound-guided perineural PRP injection can provide therapeutic effect for 1 year postinjection.Carpal Tunnel SyndromeRandomized, Double-BlindArch Phys Med Rehabil.2021
Platelet-rich plasma in treatment of patients with idiopathic carpal tunnel syndromeSenna MK, et al.Corticosteroid983 mthsPlatelet-rich plasma could be effective treatment of mild to moderate idiopathic CTS and superior to corticosteroid in improving pain, function, and distal sensory latency of median nerve.Carpal Tunnel SyndromeRandomizedClin Rheumatol.2019
Comparison of perineural platelet-rich plasma and dextrose injections for moderate carpal tunnel syndrome: A prospective randomized, single-blind, head-to-head comparative trialShen YP, et al.Dextrose526 mthsA single perineural injection of PRP reduced the CSA of the median nerve more effectively than injection of D5W at 3 and 6 months postinjection for patients with moderate CTS.Carpal Tunnel SyndromeRandomized, Double-BlindJ Tissue Eng Regen Med.2019
Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trialRaeissadat SA, et al.Wrist Brace4110 wks'The findings of this study showed that in a relatively short period of time after treatment, a single injection of platelet-rich plasma in the wrist does not significantly add to the effects of conservative treatment with wrist splints, in regards to the women pain and symptom severity, functional status and electrophysiological parameters.Carpal Tunnel SyndromeRandomizedBMC Musculoskelet Disord.2018
Platelet-rich plasma ultrasound-guided injection in the treatment of carpal tunnel syndrome: A placebo-controlled clinical study.Malahias MA, et al.Saline5012 wksThe findings of this study suggest that a single PRP ultrasound-guided injection has positive effects in patients with CTS.Carpal Tunnel SyndromeRandomizedJ Tissue Eng Regen Med.2018
Platelet-rich plasma versus corticosteroid injections for carpal tunnel syndrome.Uzun H, et al.Corticosteroid406 mthsPlatelet-rich plasma injections may be considered for the temporary symptomatic relief of mild carpal tunnel syndrome.Carpal Tunnel SyndromeJ Plast Surg Hand Surg.2017
Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trialWu YT, et al.Wrist Brace606 mthsOur study demonstrates that PRP is a safe modality that effectively relieves pain and improves disability in the patients with CTS.Carpal Tunnel SyndromeRandomizedSci Rep.2017
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
"Platelet-Rich Plasma" epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled TrialWongjarupong A, et al.Corticosteroid3024 wksNoncommercial epidural double-spin PRP yielded superior results to triamcinolone. Due to its efficacy and safety, the procedure is recommended in treating single level lumbar HNP.Lumbar Herniated DiscRandomizedBMC Musculoskelet Disord.2023
Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar radiculopathy: A Prospective, Double-Blind Randomized StudySaraf A, et al.Corticosteroid606 mthsTransforaminal injections of PRP and steroid improve short-term (up to 3 months) clinical outcome scores in discogenic lumbar radiculopathy, but clinically meaningful improvements sustaining for 6 months were provided by PRP only.Lumbar RadiculopathyRandomized, Double-BlindIndian J Orthop.2023
Effect of autologous platelet-rich plasma (PRP) on low back pain in patients with prolapsed intervertebral disc: A randomised controlled trialSingh GK, et al.Corticosteroid426 mthsPRP provided sustained relief from low back pain due to IVDP and can be recommended as a safe and promising alternative to epidural local anaesthetics and steroids.Lumbar Herniated DiscRandomized, Double-BlindIndian J Anaesth.2023
The role of intra-articular injection of autologous platelet-rich plasma versus corticosteroids in the treatment of synovitis in lumbar facet joint diseaseKotb SY, et al.Corticosteroid303 mthsBoth PRP and CS injections were effective in improving MRI-detected FJ synovitis while concurrently improving all examined parameters at follow-up after 3 months. However, PRP promoted better improvement in MRI-detected synovitis grade, suggesting that it may be a better treatment option for longer duration efficacy.Lumbar Facet Joint Synd.RandomizedSaudi Med J.2022
Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled StudyXu Z, et al.Corticosteroid12412 mthsThe results showed similar outcome for both transforaminal injections using PRP and steroid in the treatment of lumbar disc herniation, suggesting the possible application of PRP injection as a safer alternative.Lumbar Herniated DiscRandomizedNeural Plast.2021
A Randomized Double-Blind Controlled Pilot Study Comparing Leucocyte-Rich Platelet-Rich Plasma and Corticosteroid in Caudal Epidural Injection for Complex Chronic Degenerative Spinal PainRuiz-Lopez R, Tsai YC.Corticosteroid506 mthsBoth autologous LR-PRP and corticosteroid for caudal epidural injections under fluoroscopic guidance are equally safe and therapeutically effective in patients with complex chronic lumbar spinal pain. However, LR-PRP is superior to corticosteroid for a longer pain-relieving effect and improvement in quality of life.Lumbar Spinal PainRandomized, Double-BlindPain Pract.2020
A Prospective Study Comparing Platelet-Rich Plasma and Local Anesthetic (LA)/Corticosteroid in Intra-Articular Injection for the Treatment of Lumbar Facet Joint SyndromeWu J, et al.Corticosteroid466 mthsBoth autologous PRP and LA/corticosteroid for intra-articular injection are effective, easy, and safe enough in the treatment of lumbar facet joint syndrome. However, autologous PRP is a superior treatment option for longer duration efficacy.Lumbar Facet Joint Synd.RandomizedPain Pract.2017
Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled StudyTuakli-Wosornu YA, et al.Contrast Agent/Discography471 yrParticipants who received intradiskal PRP showed significant improvements in FRI, NRS Best Pain, and NASS patient satisfaction scores over 8 weeks compared with controls. Those who received PRP maintained significant improvements in FRI scores through at least 1 year of follow-up. Although these results are promising, further studies are needed to define the subset of participants most likely to respond to biologic intradiskal treatment and the ideal cellular characteristics of the intradiskal PRP injectate.Lumbar Discogenic PainRandomized, Double-BlindPM R.2016
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: a randomized clinical trial.Nouri F, et al.HA, PRP+HA1056 mthsAlthough all 3 interventions were associated with improvement of pain and function in patients with hip OA, the therapeutic effects of PRP and PRP + HA injections lasted longer (6 months), and the effects of these two interventions on patients' performance, disability, and the activities of daily living (ADL) were superior to HA in the long run. Moreover, the addition of HA to PRP was not associated with a significant increase in the therapeutic results.Osteoarthritis (Hip)RandomizedBMC Musculoskelet Disord.2022
Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritisDi Sante L, et al.HA4316 wksIntra-articular PRP had an immediate effect on pain that was not maintained at longer term follow-up when, on the contrary, the effects of intra-articular HA were evident.Osteoarthritis (Hip)RandomizedMed Ultrason.2016
Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled StudyDallari D, et al.HA, PRP+HA11112 mthsResults indicated that intra-articular PRP injections offer a significant clinical improvement in patients with hip OA without relevant side effects. The benefit was significantly more stable up to 12 months as compared with the other tested treatments. The addition of PRP+HA did not lead to a significant improvement in pain symptoms.Osteoarthritis (Hip)RandomizedAm J Sports Med.2016
Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis.Battaglia M, et al.HA10012 mthsIntra-articular injections of PRP are efficacious in terms of functional improvement and pain reduction but are not superior to HA in patients with symptomatic hip OA at 12-month follow-up.Osteoarthritis (Hip)RandomizedOrthopedics.2013
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Intra-Articular Platelet Rich Plasma vs Corticosteroid Injections for Sacroiliac Joint Pain: A Double-Blinded, Randomized Clinical TrialChen AS, et al.Corticosteroid263 mthsAlthough both groups showed improvements in pain and function, the steroid group had significantly greater response and significantly more responders than did the platelet-rich plasma group.Sacroiliac Joint (SIJ) PainRandomized, Double-BlindPain Med.2022
Steroid vs. Platelet-Rich Plasma in Ultrasound-Guided Sacroiliac Joint Injection for Chronic Low Back PainSingla V, et al.Glucocorticoid403 mthsThe intra-articular PRP injection is an effective treatment modality in low back pain involving SIJ.Sacroiliac Joint (SIJ) PainRandomizedPain Pract.2017
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Effects of platelet-rich plasma on subchondral bone marrow edema and biomarkers in synovial fluid of knee osteoarthritisLin E, et al.HA8112 mthsIntra-articular injection of PRP can significantly reduce the subchondral BME and the level of biomarkers in synovial fluid of the symptomatic knee osteoarthritis.Osteoarthritis (Knee)RandomizedKnee.2023
Clinical and Biochemical Correlation of Intra-articular Platelet-Rich Plasma and Corticosteroid Using Serum Matrix Metalloproteinase 3 (MMP-3) Levels in Osteoarthritis of Knee.Arora V, et al.Corticosteroid 96 (87 fin.)9 mthsPRP is unquestionably a better option than CS in OA of the knee based on boosting functional activity, lowering stiffness, and reducing pain, all three of which are denoted by the WOMAC and VAS scores as the effect of PRP lasts longer than CS injections for the aforesaid issues. We could not find any significant change in levels of MMP3 post PRP and CS injections, which signifies that these two modalities do not have any effect in either preventing cartilage degeneration or promoting cartilage regeneration. Our findings have shown that PRP injections are safe, minimally invasive, and effective treatment modalities for OA knee.Osteoarthritis (Knee)RandomizedCureus.2023
A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis.Tschopp M, et al.Glucocorticoid, HA95 (120 knees)6 mthsThere is no evidence that knee injections with glucocorticoid, PRP, or hyaluronic acid have superior short- or long-term effects in patients with low pain level at baseline and early- to middle-stage knee OA when compared with placebo.Osteoarthritis (Knee)Randomized, Double-Blind, Placebo-ControlledInvest Radiol.2023
Is the Combination of Platelet-Rich Plasma and Hyaluronic Acid the Best Injective Treatment for Grade II-III Knee Osteoarthritis? A Prospective Study.Ciapini G, et al.HA, HA+PRP606 mthsThe combination of platelet-rich plasma and hyaluronic acid can be effective in the treatment of grade II-III knee osteoarthritis in a short-to-mid-term scenario. It represents an innovative and valuable alternative to the administration of its two components alone.Osteoarthritis (Knee)RandomizedAdv Orthop.2023
Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trialGobbi A, et al.Adipose Tissue50 (80 knees)24 mthsAutologous microfragmented adipose tissue did not show significant superior clinical improvement compared with three LP-PRP combined with HA injections in terms of functional improvement at different follow-up points. Both procedures were safe with no major complications reporting good results at mid-term follow-up, improving knee function, pain, and quality of live regardless of age and gender.Osteoarthritis (Knee)RandomizedEur J Orthop Surg Traumatol.2023
Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritisKüçükakkaş O, et al.HA406 mths[…] both treatment approaches had significant positive effects on pain, stiffness, and function and no superiority was observed over each other.Osteoarthritis (Knee)RandomizedActa Orthop Belg.2022
Comparison of clinical outcome, cartilage turnover, and inflammatory activity following either intra-articular or a combination of intra-articular with intra-osseous platelet-rich plasma injections in osteoarthritis knee: A randomized, clinical trial.Barman A, et al.Saline9612 wksSignificant clinical improvements were noticed following IA-PRP and IA-IO-PRP injections compared to IA-NS injections. Both PRP groups reported a significant reduction in ESR, CRP, and CTX-II levels at 12 weeks. Persons in the IA+IO-PRP group reported significant changes in u-NTX-I level and knee-USG findings.Osteoarthritis (Knee)Randomized, Single-BlindInjury.2022
Serial Platelet-Rich Plasma Intra-articular Injections in Kellgren and Lawrence Grade IV Knee Joint Osteoarthritis: A Prospective Blinded Placebo-Controlled Interventional Study.Saraf A, et al.Saline90 (84 fin.)6 mthsSerial Intra-articular Injections of autologous PRP mildly improve short-term subjective pain and knee function scores in patients of Grade IV KOA without any major complications.Osteoarthritis (Knee)RandomizedIndian J Orthop.2022
Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis.Pretorius J, et al.Corticosteroid 29 (58 knees)6 mthsBoth corticosteroids and PRP interventions are effective in improving pain, stiffness, and function in patients with bilateral knee osteoarthritis up to six months with no statistically significant difference between the two.Osteoarthritis (Knee)Randomized, Double-BlindCureus.2022
Assessment of the effectiveness and satisfaction of platelet-rich plasma compared with hyaluronic acid in knee osteoarthritis at minimum 7-year follow-up: A post hoc analysis of a randomized controlled trial.Wang Z, et al.HA100 (85 fin.)79 mthsPRP was more effective than HA in survival and re-intervention rates, VAS, and WOMAC, although there were no significant differences in the imaging evaluation between the two groups. Furthermore, patients treated with PRP were associated with higher satisfaction compared with HA.Osteoarthritis (Knee)RandomizedFront Bioeng Biotechnol.2022
Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial.Wang YC, et al.HA1106 mthsThis study revealed that both PRP and HA can yield significant improvements in WOMAC scores at 6-month follow-up without any between-group differences at 1-, 3-, and 6-month follow-ups. Thus, both the single-injection regimens of PRP and HA can improve the functional outcomes for treating early-stage knee OA.Osteoarthritis (Knee)Randomized, Double-BlindMedicina (Kaunas).2022
Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Randomized Controlled Trial.Baria M, et al.Adipose Tissue586 mthsA single injection of either PRP or MFAT resulted in a clinically meaningful improvement for patients with knee OA at 6 months, with no difference between treatment groups.Osteoarthritis (Knee)RandomizedOrthop J Sports Med.2022
Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-Year Follow-up.Zaffagnini S, et al.Adipose Tissue11824 mthsA single intra-articular injection of MF-AT was not superior to PRP, with comparable low numbers of failures and adverse events and without disease progression. No differences were found in clinical and imaging results between the 2 biological approaches.Osteoarthritis (Knee)RandomizedAm J Sports Med.2022
A Comparative Study of Osteoarthritis Knee Arthroscopy versus Intra-Articular Platelet Rich Plasma Injection: A Randomised Study.Singh N, et al.Arthroscopy709 mthsThis study suggested that both PRP as well as arthroscopy provide a reduction in WOMAC and VAS scores for pain among cases of knee osteoarthritis. Most effective reduction is observed at three months follow-up which thereafter tends to diminish. Of the two modalities, PRP seemed to have an edge over arthroscopic debridement, however, this efficacy was more pronounced for Kellgren-Lawrence Grade 2 as compared to Grade 3.Osteoarthritis (Knee)RandomizedMalays Orthop J.2022
Intra-articular injections of platelet-rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritisChu J, et al.Sham Saline61060 mthsIn this randomized clinical trial of patients with KOA, P-PRP was superior to sham saline in treating KOA. P-PRP was effective for achieving at least 24 months of symptom relief and slowing the progress of KOA, with both P-PRP and saline being comparable in safety profiles.Osteoarthritis (Knee)Randomized, Double-Blind, Multi-CenterKnee Surg Sports Traumatol Arthrosc.2022,15
The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial.Raeissadat SA, et al.PRGF, HA, Ozone23812 mthsOzone injection had rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6 months and at the 6-month follow up, PRP, PRGF and HA were superior to ozone. Only patients in PRP and PRGF groups improved symptoms persisted for 12 months. Therefore, these products could be the preferable choices for long-term management.Osteoarthritis (Knee)RandomizedBMC Musculoskelet Disord.2021
Clinical Efficacy of Platelet-Rich Plasma Injection and Its Association With Growth Factors in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial As Compared With Hyaluronic AcidPark YB, et al.HA1106 mthsPRP had better clinical efficacy than HA. High concentrations of growth factors were observed in patients who scored above the MCID for clinical outcomes in the PRP group. These findings indicate that concentration of growth factors needs to be taken into consideration for future investigations of PRP in knee osteoarthritis.Osteoarthritis (Knee)Randomized, Double-BlindAm J Sports Med.2021
Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trialDório M, et al.Plasma, Saline6224 wksPRP and plasma were not superior to placebo for pain and function improvement in KOA over 24 weeks. The PRP group had a higher frequency of mild transitory increase in pain.Osteoarthritis (Knee)Randomized, Double-Blind, Placebo-ControlledBMC Musculoskelet Disord.2021
[Platelet rich plasma intra-articular and extra-articular injection for the treatment of knee osteoarthritis]Du W, et al.HA486 mthsIntra-articular and extra-articular injection of PRP could relieve pain symptoms and improve function of knee joint with higher safety, although the short-term effect is not significantly different from traditional treatment, its medium-long-term effect is stable. It is a safe and effective method for the treatment of knee osteoarthritis.Osteoarthritis (Knee)RandomizedZhongguo Gu Shang.2020
Comparison of two platelet rich plasma formulations with viscosupplementation in treatment of moderate grade gonarthrosis: A prospective randomized controlled studyYaradilmis YU, et al.HA9012 mthsPRP injections produced superior results than HA. LR-PRP seems to be the most effective treatment modality for moderate gonarthrosis especially in normal weighted men at the 6th decade of age.Osteoarthritis (Knee)RandomizedJ Orthop. 2020
The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis.Elik H, et al.Saline606 mthsPRP treatment had positive effects on the pain, physical function, and quality of life of patients with knee OA, but it did not increase cartilage thickness.Osteoarthritis (Knee)RandomizedJ Back Musculoskelet Rehabil.2020
MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial)Raeissadat SA, et al.Saline23 (46 knees)8 mthsIn this study, in addition to the effect of PRP on VAS and WOMAC, there was a significant effect on radiologic characteristics (patellofemoral cartilage volume and synovitis). For further evaluation, a longer study with a larger sample size is recommended.Osteoarthritis (Knee)Randomized, Double-BlindJ Pain Res.2020
Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study.Kesiktas FN, et al.Peptide, HA543 mthsAs a result, pain relief and functional improvement were obtained after the intra-articular HA, peptide, and PRP injections in OA, and decrease in pain was better in the peptide group.Osteoarthritis (Knee)RandomizedClin Rheumatol.2020
Bone Marrow Aspirate Concentrate Is Equivalent to Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis at 1 Year: A Prospective, Randomized Trial.Anz AW, et al.BMC9012 mthsBoth PRP and BMC were effective in improving patient-reported outcomes in patients with mild to moderate knee OA for at least 12 months; neither treatment provided a superior clinical benefit. Autologous PRP and BMC showed promising clinical potential as therapeutic agents for the treatment of OA, and while PRP has strong clinical evidence to support its efficacy, BMC has limited support. This study did not prove BMC to be superior to PRP, providing guidance to clinicians treating OA. It is possible that the results were affected by patients knowing that there was no control group.Osteoarthritis (Knee)RandomizedOrthop J Sports Med.2020
Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trialTavassoli M, et al.HA9512 wksPRP is a safe and efficient therapeutic option for treatment of knee osteoarthritis. It was demonstrated to be significantly better than hyaluronic acid. We also found that the efficacy of PRP increases after multiple injections.Osteoarthritis (Knee)RandomizedWorld J Orthop. 2019
The combined use of platelet rich plasma and hyaluronic acid: prospective results for the treatment of knee osteoarthritisRapila R, et al.HHA6012 mthsBased on our results we can conclude that the combined PRP and HHA treatment is not only a safe and efficacious procedure which can provide functional benefit but is also significantly better than HHA injective therapy alone, as demonstrated by the comparison within our cohort.Osteoarthritis (Knee)J Biol Regul Homeost Agents. 2019
Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled studyHuang Y, et al.HA, CS12012 mthsIntra-articular PRP injections into the knee for symptomatic early stages of KOA are a valid treatment option. The clinical efficacy of IA-PRP is comparable to that of the IA-HA and IA-CS forms after 3 months and the long-term efficacy of IA PRP is superior to IA-HA and IA-CS.Osteoarthritis (Knee)RandomizedOrthopade. 2019
Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical TrialLin K-Y, et al.HA53 (87 knees)12 mthsIntra-articular injections of leukocyte-poor PRP can provide clinically significant functional improvement for at least 1 year in patients with mild to moderate osteoarthritis of the knee.Osteoarthritis (Knee)Randomized, Double-Blind, Placebo-ControlledArthroscopy. 2019
Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled TrialDi Martino A, et al.HA19224 mthsBoth treatments were effective in improving knee functional status and symptoms over time. PRP did not provide an overall superior clinical improvement compared with HA in terms of either symptomatic-functional improvement at different follow-up points or effect duration.Osteoarthritis (Knee)Randomized, Double-BlindAm J Sports Med.2019
Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study.Simental-Mendia M,PRP Multi Inject3548 wksThe triple infiltration of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up.Osteoarthritis (Knee)RandomizedActa Reumatol Port.2019
Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritisYu W, et al.HA, HA+PRP36052 wksPRP and HA combination treatment significantly improved arthralgia, reduced humoral and cellular immune responses and promoted angiogenesis, which improved the patients' histological parameters compared with PRP or HA treatment alone. These results suggested that PRP and HA combination treatment may be a potential treatment option for patients with knee osteoarthritis in the future.Osteoarthritis (Knee)Randomized, Double-Blind, Placebo-ControlledExp Ther Med.2018
Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trialBuendia-López D, et al.HA, NSAID9852 wksLeukocyte-poor platelet-rich plasma (LP-PRP) injections are better in terms of clinical improvement with respect to HA injections or oral NSAID treatment in knee osteoarthritis patients at the 52-week follow-up. Moreover, a single LP-PRP injection is effective. However, LP-PRP has no influence on cartilage progression.Osteoarthritis (Knee)RandomizedJ Orthop Traumatol2018
Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritisAhmad HS, et al.HA896 mthsIntra-articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra-articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion.Osteoarthritis (Knee)RandomizedInt J Rheum Dis.2018
Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritisSu K, et al.HA8618 mthsThe combination of intraosseous with intra-articular injections of PRP resulted in a significantly superior clinical outcome, with sustained lower VAS and WOMAC scores and improvement in quality of life within 18 months.Osteoarthritis (Knee)RandomizedClin Rheumatol.2018
Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With ViscosupplementationLouis ML, et al.HA543 mthsCurrent results indicated that a single injection of very pure PRP offers a significant clinical improvement in the management of knee osteoarthritis, equivalent to a single HA injection in this patient population. Moreover, a significant correlation between the doses of TGF-β1 and PDGF-AB and the worsening of WOMAC score 3 months after the procedure was found.Osteoarthritis (Knee)Randomized, Double-BlindArthroscopy.2018
Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trialLisi C, et al.HA586 mthsActivated platelet-rich plasma reduces articular damage as evident at MRI, as soon as six months after treatment; it reduces pain and improves patient's function and overall quality of life.Osteoarthritis (Knee)RandomizedClin Rehabil.2018
Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factorsHuang G, et al.Saline366 (350 fin.)[8 wks]In conclusion, treatment with PRP for patients with knee osteoarthritis presented beneficial effects in alleviating joint inflammation, cartilage destruction and bone damage, and repairing joint tissue. These results suggested that PRP may be a potential therapeutic agent for knee osteoarthritis.Osteoarthritis (Knee)Randomized, Double-BlindExp Ther Med.2018
Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee OsteoarthritisWu YT, et al.Saline20 (40 knees)6 mthsPlatelet-rich plasma treatment significantly improves pain, stiffness, and disability in patients with knee osteoarthritis compared with normal saline treatment. Additional strength training is recommended to enhance muscle strength recovery.Osteoarthritis (Knee)RandomizedAm J Phys Med Rehabil.2018
Single-dose intra-articular corticosteroid injection prior to platelet-rich plasma injection resulted in better clinical outcomes in patients with knee osteoarthritis: A pilot study.Camurcu Y, et al.Corticosteroid 11512 mthsAccording to our results, IA MP injection prior to PRP injection resulted in significantly better clinical outcomes compared to PRP and MP injections alone in patients who had mild to moderate knee OA.Osteoarthritis (Knee)J Back Musculoskelet Rehabil.2018
Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trialGörmeli G, et al.HA1626 mthsThe clinical results of this study suggest IA PRP and HA treatment for all stages of knee OA. For patients with early OA, multiple (3) PRP injections are useful in achieving better clinical results. For patients with advanced OA, multiple injections do not significantly improve the results of patients in any group.Osteoarthritis (Knee)Randomized, Double-Blind, Placebo-ControlledKnee Surg Sports Traumatol Arthrosc.2017
Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee OsteoarthritisCole BJ, et al.HA11112 mthsWe found no difference between HA and PRP at any time point in the primary outcome measure: the patient-reported WOMAC pain score. Significant improvements were seen in other patient-reported outcome measures, with results favoring PRP over HA. Preceding a significant difference in subjective outcomes favoring PRP, there was a trend toward a decrease in 2 proinflammatory cytokines, which suggest that the anti-inflammatory properties of PRP may contribute to an improvement of symptoms.Osteoarthritis (Knee)Randomized, Double-BlindAm J Sports Med.2017
Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical TrialJoshi Jubert N, et al.Corticosteroid 756 mthsA single PRP intra-articular injection is effective for relieving pain and improving activities of daily living and quality of life in late-stage knee OA. For patients with late-stage knee OA who are 67 years or older, 1 intra-articular injection of PRP has similar results to 1 shot of corticosteroid.Osteoarthritis (Knee)Randomized, Double-BlindOrthop J Sports Med.2017
Comparison of Efficiency Between Corticosteroid and Platelet Rich Plasma Injection Therapies in Patients With Knee OsteoarthritisUslu Güvendi E, et al.Corticosteroid 506 mthsOur findings revealed that PRP is a safe treatment option and efficient in osteoarthritis symptom control up to six months after application. Treatment response obtained with corticosteroid injection has a shorter duration than PRP treatment.Osteoarthritis (Knee)RandomizedArch Rheumatol.2017
Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone optionsDuymus TM, et al.HA, Ozone10212 mthsIn the treatment of mild-moderate knee OA, PRP was more successful than HA and ozone injections, as the application alone was sufficient to provide at least 12 months of pain-free daily living activities.Osteoarthritis (Knee)RandomizedKnee Surg Sports Traumatol Arthrosc.2017
Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care SystemMontañez-Heredia E, et al.HA556 mthsPRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades.Osteoarthritis (Knee)RandomizedInt J Mol Sci. 2016
Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the kneeLana JF, et al.HA, HA+PRP10512 mthsThe findings of the study support the use of autologous PRP as an effective treatment of mild to moderate knee osteoarthritis. It also shows that the combination of HA and PRP resulted to better outcomes than HA alone up to 1 year and PRP alone up to 3 months. Furthermore, the results suggest that combination of PRP and HA could potentially provide better functional outcomes in the first 30 days after treatment with both PRP and HA alone.Osteoarthritis (Knee)Randomized, Multi-Center, Double-BlindJ Stem Cells Regen Med. 2016
Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis.Simental-Mendía M, et al.Pharma6524 wksTreatment with LP-PRP injections resulted in a significantly better clinical outcome than did treatment with acetaminophen, with sustained lower EVA and WOMAC scores and improvement in quality-of-life (higher SF-12 score). Therapy with LP-PRP may positively modify the inflammatory joint environment by counteracting IL-1β action.Osteoarthritis (Knee)RandomizedArch Orthop Trauma Surg.2016
Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot studyPaterson KL, et al.HA3712 wksThis study provides proof-of-concept evidence concerning the feasibility and safety of PA-PRP injections necessary to inform a larger clinical trial in people with knee OA. Our preliminary results also suggest PA-PRP improves self-reported pain, symptoms and lower extremity function, however no between-group differences were found. Photo-activated PRP may provide a safe and effective novel treatment for knee OA.Osteoarthritis (Knee)Randomized, Double-BlindBMC Musculoskelet Disord.2016
Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial)Raeissadat SA, et al.HA16012 mthsThis study suggests that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment.Osteoarthritis (Knee)RandomizedClin Med Insights Arthritis Musculoskelet Disord. 20152562477610.4137/CMAMD.S178941.1
Treatment of knee osteoarthritis with platelet-rich plasma in comparison with transcutaneous electrical nerve stimulation plus exercise: a randomized clinical trial.Angoorani H, et al.Exercise+TENS548 wksIntraarticular injection of PRP is an effective, safe method for short-term treatment of patients with knee joint osteoarthritis.Osteoarthritis (Knee)RandomizedMed J Islam Repub Iran.2015
Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.Rayegani SM, et al.Exercise626 mthsThis study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.Osteoarthritis (Knee)RandomizedOrthop Rev (Pavia).2014
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trialMunde K, et al.non-PRP806 mthsThese findings demonstrate that PRP can be used as an adjunct therapy for ACL reconstruction, enhancing graft healing and improving patient outcomes.ACL reconstructionRandomizedRegen Med.2023
Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study.Kaminski R, et al.Saline72> 12 mthsOur trial indicates that percutaneous meniscal trephination augmented with PRP results in a significant improvement in the rate of chronic meniscal tear healing and this procedure decreases the necessity for arthroscopy in the future (8% vs. 28%, P = 0.032).Meniscal LesionRandomized, Double-BlindInt J Mol Sci.2019
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis.Paget LDA, et al.Saline100 (98 fin.)52 wksFor patients with ankle osteoarthritis, PRP injections did not improve ankle symptoms and function over 52 weeks compared with placebo injections.Osteoarthritis (Ankle)RandomizedMed Ultrason.2023
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Botulinum toxin A versus platelet rich plasma ultrasound-guided injection in the treatment of plantar fasciitis: A randomised controlled trialRuiz-Hernández IM, et al.Botulinum toxin A591 yrPRP and BTX-A injections are effective in patients with plantar fasciitis with BTX-A achieving better short-term pain reduction and PRP better long-term results.Plantar FasciitisRandomizedFoot Ankle Surg.2024
Comparative study of local injections of autologous platelet rich plasma versus corticosteroid in management of chronic plantar fasciitisSathyendra KG, et al.Corticosteroid706 mthsPRP was more effective in chronic plantar fasciitis patients compared to corticosteroids with pain relief coming after first 1st, 3rd and 6th month of the injection.Plantar FasciitisRandomizedJ Clin Orthop Trauma.2023
Platelet-rich plasma or extracorporeal shockwave therapy for plantar fasciitisHaddad S, et al.ESWT10424 wksHere we showed that PRP injections and ESWT are both beneficial in pain amelioration in patients with chronic plantar fasciitis. We also indicated that PRP injections were associated with better pain reduction results compared to ESWT.Plantar FasciitisRandomizedInt J Burns Trauma.2021
Positive Effect of Platelet-Rich Plasma on Pain in Plantar Fasciitis: A Double-Blind Multicenter Randomized Controlled TrialPeerbooms JC, et al.Corticosteroid11512 mthsTreatment of patients with chronic plantar fasciitis with PRP seems to reduce pain and increase function more as compared with the effect of corticosteroid injection.Plantar FasciitisRandomized, Double-Blind, Multi-CenterAm J Sports Med.2019
Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled TrialUğurlar M, et al.ESWT, Prolo, Corticosteroid15836 mths'The corticosteroid injection was more effective in the first 3 months and extracorporeal shock wave therapy was an effective treatment method in the first 6 months in regard to pain. The corticosteroid injection lost its effectiveness during the follow-up period. The effect of prolotherapy and platelet-rich plasma was seen within 3 to 12 months; however, at the 36-month follow-up point, no differences were found among the 4 treatments.Plantar FasciitisRandomizedJ Foot Ankle Surg.2018
Plantar fasciitis: A randomized comparative study of platelet rich plasma and low dose radiation in sportspersonsGogna P, et al.Low Dose Radiation406 mths'PRP is as good as LDR in patients with chronic recalcitrant plantar fasciitis not responding to physical therapy.Plantar FasciitisRandomizedFoot (Edinb).2016
Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitisMonto RR.Glucocorticoid4024 mthsPRP was more effective and durable than cortisone injection for the treatment of chronic recalcitrant cases of plantar fasciitis.Plantar FasciitisRandomizedFoot Ankle Int.2014
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Minimally Invasive Treatment of Trapeziometacarpal Osteoarthritis: Results of a Blinded Randomized Controlled TrialWinter R, et al.Adipose Tissue, Saline952 yrs'In addition to pain reduction, the combination of autologous fat and PRP yields a relevant improvement in hand function and a corresponding improvement in quality of life. This treatment seems to be a viable and safe alternative to short-acting glucocorticoids.Osteoarthritis (Hand)RandomizedPlast Reconstr Surg.2023
Platelet-Rich Plasma versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Randomized Controlled Clinical TrialMalahias MA, et al.Corticosteroid3312 mthsAfter 12 months' follow-up, the IA-PRP treatment has yielded significantly better results in comparison with the corticosteroids, in terms of VAS score (P = 0.015), Q-DASH score (P = 0.025), and patients' satisfaction (P = 0.002). Corticosteroids offer short-term relief of symptoms, but IA-PRP might achieve a lasting effect of up to 12 months in the treatment of early to moderate symptomatic TMJ arthritis.Osteoarthritis (Hand)RandomizedCartilage.2018
PublicationAuthorPub. YearCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPubmedDOIID-No
Platelet-Rich Plasma for Patellar Tendinopathy: A Randomized Controlled Trial of Leukocyte-Rich PRP or Leukocyte-Poor PRP Versus SalineScott A, et al.2020Saline5712 mthsCombined with an exercise-based rehabilitation program, a single injection of LR-PRP or LP-PRP was no more effective than saline for the improvement of patellar tendinopathy symptoms.Patellar TendinopathyRandomizedAm J Sports Med.
Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trialDragoo JL, et al.2014Dry Needling2326 wksA therapeutic regimen of standardized eccentric exercise and ultrasound-guided leukocyte-rich PRP injection with DN accelerates the recovery from patellar tendinopathy relative to exercise and ultrasound-guided DN alone, but the apparent benefit of PRP dissipates over time.Patellar TendinopathyRandomized, Double-BlindAm J Sports Med.
Leucocyte-Rich Platelet-Rich Plasma Treatment of Gluteus Medius and Minimus Tendinopathy: A Double-Blind Randomized Controlled Trial With 2-Year Follow-up.Fitzpatrick J, et al.2019Corticosteroid802 yrsAmong patients with chronic gluteal tendinopathy and a length of symptoms >15 months, a single intratendinous LR-PRP injection performed under ultrasound guidance results in greater improvement in pain and function than a single CSI. The improvement after LR-PRP injection is sustained at 2 years, whereas the improvement from a CSI is maximal at 6 weeks and not maintained beyond 24 weeks.Gluteal TendinopathyRandomized, Double-BlindAm J Sports Med.
Comparison of Clinical and Functional Outcomes after Platelet-Rich Plasma Injection and Corticosteroid Injection for the Treatment of de Quervain's TenosynovitisKumar V, et al.2022Corticosteroid6012 mths'Both the modalities are equally effective in the management of DQTSV remittance. PRP is equally effective as corticosteroid in reducing symptoms of first dorsal compartment stenosing tenosynovitis. PRP may have a lower complication profile, however, this benefit should be weighed against the slight increase in cost and time of PRP preparation and Quervain's TenosynovitisRandomizedJ Wrist Surg.
Effect of platelet-rich plasma on healing tissues in acute ruptured Achilles tendon: a human immunohistochemistry studyAlsousou J, et al.2015Saline206 wksThis is the first study, to our knowledge, to report the immunohistochemical response of ruptured human Achilles tendon to PRP. The findings reveal that locally applied PRP enhanced the maturity of the healing tendon tissues by promoting better collagen I deposition, decreased cellularity, less vascularity, and higher glycosaminoglycan content when compared with control samples. Further work is required to determine the longer term effects of the use of PRP in musculoskeletal diseases.Achilles Tendon RuptureLancet. (Poster Abstact)
Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective StudyBoesen AP, et al.2017High-Volume Injection, Saline576 mthsTreatment with HVI or PRP in combination with eccentric training in chronic AT seems more effective in reducing pain, improving activity level, and reducing tendon thickness and intratendinous vascularity than eccentric training alone. HVI may be more effective in improving outcomes of chronic AT than PRP in the short term.Achilles TendinopathyRandomized, Double-BlindAm J Sports Med.
Ultrasound-Guided Injection Therapy of Achilles Tendinopathy With Platelet-Rich Plasma or Saline: A Randomized, Blinded, Placebo-Controlled TrialKrogh TP, et al.2016Saline243 mthsPRP injection did not result in an improved VISA-A score over a 3-month period in patients with chronic AT compared with placebo. The only secondary outcome demonstrating a statistically significant difference between the groups was change in tendon thickness; this difference indicates that a PRP injection could increase tendon thickness compared with saline injection. The conclusions are limited to the 3 months after treatment owing to the large dropout rate.Achilles TendinopathyRandomizedAm J Sports Med.
One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trialde Jonge S, et al.2011Saline541 yr'This randomized controlled trial showed no clinical and ultrasonographic superiority of platelet-rich plasma injection over a placebo injection in chronic Achilles tendinopathy at 1 year combined with an eccentric training program.Achilles TendinopathyRandomized, Double-BlindAm J Sports Med.

Other Indications

PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Platelet-rich plasma therapy for temporomandibular joint osteoarthritis: A randomized controlled trialLiu SS, et al.HA706 mthsWithin the limitations of the study it seems that the application of PRP therapy in TMJ-OA is should be considered whenever possible.TMJ OARandomizedJ Craniomaxillofac Surg.2023
Intra-articular injection of hyaluronic acid versus platelet-rich plasma following single puncture arthrocentesis for the management of internal derangement of TMJ: A double-blinded randomised controlled trialDasukil S, et al.HA906 mthsWithin the limitations of the present study, it can be concluded that intra-articular PRP may be preferable over HA whenever appropriate, following single needle arthrocentesis in the treatment of TMJ internal derangement.TMJ internal derangementRandomized, Double-BlindJ Craniomaxillofac Surg.2022
Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint OsteoarthritisAsadpour N, etal.HA, HA+PRP306 mthsCombined HA and PRP injection following arthrocentesis is more effective than HA or PRP alone in the management of TMJ-OA.TMJ OARandomizedJ Oral Maxillofac Surg.2022
Platelet-rich plasma improves esthetic postoperative outcomes of maxillofacial surgical proceduresMenchisheva Y, et al.Control1003 mthsThe use of PRP had a pronounced beneficial therapeutic effect in influencing the esthetic outcomes of surgical interventions.Plastic and reconstructive surgeryRandomizedActa Chir Plast.2021
Effect of platelet-rich plasma in alveolar distraction osteogenesis: a controlled clinical trialMenezes DJ, et al.Control14105 daysThe addition of platelet-rich plasma had a protective effect on the mucosa around the distractor, which decreased the potential for complications.Alveolar distraction osteogenesisRandomizedBr J Oral Maxillofac Surg.2016
Is Arthrocentesis Plus Platelet-Rich Plasma Superior to Arthrocentesis Alone in the Treatment of Temporomandibular Joint Osteoarthritis? A Randomized Clinical TrialCömert Kiliç S, et al.Joint Aspiration, Aspiration+PRP30 (47 joints)12 mthsThese findings suggested that arthrocentesis and PRP injections constitute a safe and promising method for the treatment of TMJ-OA that is superior to arthrocentesis alone.TMJ OARandomizedJ Oral Maxillofac Surg.2015
Platelet-Rich Plasma Injection as an Effective Treatment for Temporomandibular Joint OsteoarthritisHegab AF, et al.HA5012 mthsPRP performed better than HA acid in the treatment of TMJ-OA during long-term follow-up in terms of pain reduction and increased interincisal distance. Future studies will focus on the synergistic actions of HA and PRP in the treatment of TMJ-OA.TMJ OARandomizedJ Oral Maxillofac Surg.2015
Effect of autologous platelet-rich plasma on bone regeneration in mandibular fracturesDaif ET.Control246 mthsIt can be concluded that direct application of the PRP along the fracture lines may enhance the bone regeneration in mandibular fractures.Mandibular fractureRandomizedDent Traumatol.2013
Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trialEskan MA, et al.Allograft284 mthsThese clinical and histologic findings suggest that PRP enhanced bone regeneration and resulted in increased horizontal bone gain and percentage vital bone.Ridge augmentationRandomizedJ Periodontol.2013
Extraction socket preservation graft before implant placement with calcium sulfate hemihydrate and platelet-rich plasma: a clinical and histomorphometric study in humansKutkut A, et al.Collagen resorbable plug dressing163 mthsMGCSH mixed with PRP showed greater vital bone volume at 3 months with rapid enhancement of bone healing compared to PRP-free collagen resorbable graft.Dental ImplantRandomizedJ Periodontol.2012
Sinus grafting using autogenous bone and platelet-rich plasma: histologic outcomes in humans.Aimetti M, et al.Autogenous bone46 mthsDespite similar clinical and radiographic healing patterns, a higher bone-to-implant contact rate was observed on the implants placed in bone and PRP than on those placed in bone only (46.75% +/- 13.6% versus 20.5% +/- 5.57%, respectively).Sinus augmentationRandomizedInt J Periodontics Restorative Dent.2008
Immediate loading of the grafted maxillary sinus using platelet rich plasma and autogenous bone: a preliminary study with histologic and histomorphometric analysisLee CY, et al.--418 mthsThe preliminary results of this clinical study indicate that immediate nonfunctional loading using PRP and 50% autogenous bone combined with different substitute graft materials is a predictable protocol in the grafted maxillary sinus as early as 4 months of postgrafting. The high implant survival rate is due to the early formation of large percentages of new vital bone as confirmed by using histologic and histomorphometric analysis.Dental implantRandomizedImplant Dent.2008
Platelet-rich plasma activity on maxillary sinus floor augmentation by autologous boneConsolo U, et al.Autologous bone167 mthsOur results seem to indicate a certain regenerative potential of PRP when used with autologous bone. The effect of this enhancement of bone regeneration appeared to be restricted to shorter treatment times. A progressive extinguishment of the PRP effect is recorded after an interval longer than 6-7 months.Sinus augmentationRandomizedClin Oral Implants Res.2007
Influence of the application of platelet-enriched plasma in oral mucosal wound healingLindeboom JA, et al.Placebo105 wksPRP has a strong stimulant effect on capillary regeneration in wound healing. These effects are mainly noticeable during the early stages of wound healing.Sinus augmentationRandomizedClin Oral Implants Res.2007
PublicationAuthorCompared toNo. PatientsFollow-UpRecommends PRPConclusionIndicationStudy DesignJournalPub. YearPubmedDOIID-No
Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical TrialMasterson TA, et al.Saline616 mths'The results of our prospective, double-blind, randomized, placebo-controlled clinical trial suggest that 2 injections of intracavernosal platelet-rich plasma separated by 1 month in men with mild to moderate erectile dysfunction is safe, but we found no difference in efficacy between platelet-rich plasma and placebo.Erectile DysfunctionRandomized, Double-BlindJ Urol.2023
Is Platelet Rich Plasma Safe and Effective in Treatment of Erectile Dysfunction? Randomized Controlled StudyShaher H, et al.Saline1006 mthsPRP is a safe and promising method for the improvement of mild to moderate erectile dysfunction.Erectile DysfunctionRandomizedUrology.2023
Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical TrialPoulios E, et al.Saline606 mthsPRP intracavernosal injections may be a promising addition to the urologist's armamentarium for the management of ED. Still, further high-quality studies are warranted to corroborate our findings.Erectile DysfunctionRandomized, Double-BlindJ Sex Med.2021