Platelet-Rich Plasma Library
The tables below show randomized controlled trials that used Platelet-Rich Plasma (PRP) to treat various indications sorted by publication year. Only studies that are listed in the US National Library of Medicine (PubMed) were included. We try to add the latest and most actual trials only. However, the tables are just an overview and do not claim to be complete.
Click on the green “+” button in the first column of a trial to view more information and trial conclusion.
PRP Injection Therapy in Orthopedics
Shoulder
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effectiveness of single intra-bursal injection of platelet-rich plasma against corticosteroid under ultrasonography guidance for shoulder impingement syndrome: a randomized clinical trial. | Hewavithana PB, et al. | Corticosteroid | 60 | 1 yr |  | PRP and triamcinolone in the SASD bursa could be considered as safe treatment options for SIS under ultrasonography guidance. While triamcinolone was effective in short-term pain reduction, PRP was effective in long-term improvement in shoulder abduction. | Shoulder Impingement Syndrome (SIS) | Randomized | Skeletal Radiol. | 2024 | https://pubmed.ncbi.nlm.nih.gov/37398735/ | 10.1007/s00256-023-04373-w | 9.4 | ||
| Comparing the Efficacy of Intra-articular Platelet-Rich Plasma and Corticosteroid Injections in the Management of Frozen Shoulder: A Randomized Controlled Trial | Somisetty TK, et al. | Corticosteroid | 68 | 24 wks | | Our findings suggest that IA PRP injections provide better long-term results than IA CS injections for managing FS. Platelet-rich plasma can be used as a treatment modality for better outcomes, particularly when the patient is contraindicated or refuses CS treatment. Further research is needed to evaluate the efficacy of these treatment modalities at different stages of FS and explore the potential benefits of ultrasound-guided injections. | Adhesive Capsulitis | Randomized | Cureus. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37398735/ | 10.7759/cureus.39728 | 9.3 | ||
| Effects of Platelet-Rich Plasma in Tear Size Reduction in Partial-Thickness Tear of the Supraspinatus Tendon Compared to Corticosteroids Injection | Tanpowpong T, et al. | Corticosteroid | 29 | 6 mths | | Intralesional PRP injection can reduce the tear size in partial-thickness tears of the supraspinatus tendon. Subacromial steroid injection did not significantly affect the tear size. While CS improved functional scores compared with baseline, PRP resulted in better improvement 6 months post-injection. | Rotator Cuff Tear | Randomized | Sports Med Open. | 2023 | https://pubmed.ncbi.nlm.nih.gov/36752928/ | 10.1186/s40798-023-00556-w | 9.5 | ||
| Comparison of the Efficacy of Platelet-Rich Plasma (PRP) and Local Corticosteroid Injection in Periarthritis Shoulder: A Prospective, Randomized, Open, Blinded End-Point (PROBE) Study | Gupta GK, et al. | Corticosteroid | 60 | 24 wks | | The triamcinolone group showed better short-term outcomes whereas PRP showed better long-term outcomes in reducing pain and disability scores in terms of VAS and DASH scores. | Adhesive Capsulitis | Randomized | Cureus. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36262947/ | 10.7759/cureus.29253 | 9.6 | ||
| Efficacy of Ultrasound-Guided Glenohumeral Joint Injections of Leukocyte-Poor Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-Blind Controlled Trial | Kirschner JS, et al. | HA | 70 | 12 mths | | There were no differences in pain and functional outcomes after a single injection of LP-PRP versus HA. However, significant improvements in pain and function were observed after both treatments in patients with glenohumeral osteoarthritis. | Osteoarthritis (Shoulder) | Randomized, Double-Blind | Clin J Sport Med. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35316820/ | 10.1097/JSM.0000000000001029 | 9.7 | ||
| Comparison of Functional Outcome Between Intra-Articular Injection of Corticosteroid Versus Platelet-Rich Plasma in Frozen Shoulder: A Randomized Controlled Trial | Shahzad HF, et al. | Corticosteroid | 202 | 12 wks | | Intra-articular injection of PRP resulted in a substantial improvement in the VAS score, UCLA, and ROM when compared to intra-articular corticosteroid injection in patients with FS. | Adhesive Capsulitis | Randomized | Cureus. | 2021 | https://pubmed.ncbi.nlm.nih.gov/35103139/ | 10.7759/cureus.20560 | 9.8 | ||
| Comparison of a Platelet-Rich Plasma Injection and a Conventional Steroid Injection for Pain Relief and Functional Improvement of Partial Supraspinatus Tears | Thepsoparn M, et al. | Corticosteroid | 31 | 6 mths | | An injection using either a corticosteroid or LP-PRP resulted in a similar reduction in pain and improvement in function at 1 month in patients with a partial supraspinatus tear. However, PRP showed superior benefits over the corticosteroid at 6-month follow-up. | Rotator Cuff Tear | Randomized | Orthop J Sports Med. | 2021 | https://pubmed.ncbi.nlm.nih.gov/34485587/ | 10.1177/23259671211024937 | 9.15 | ||
| Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study. | Karabaş Ç, et al. | Physical Therapy | 40 | 12 wks | | The addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis. | Adhesive Capsulitis | Randomized | Turk J Phys Med Rehabil. | 2021 | https://pubmed.ncbi.nlm.nih.gov/35141486/ | 10.5606/tftrd.2021.6690 | 10.2 | ||
| Comparison of the Effectiveness of Platelet-Rich Plasma, Corticosteroid, and Physical Therapy in Subacromial Impingement Syndrome | Pasin T, et al. | Corticosteroid, Phys. Therapy/TENS/US | 90 | 8 wks | ' | All three treatment modalities were effective in the treatment of SAIS. However, we suggest that the inexpensive and noninvasive methods of physical therapy and exercise should be the first preferred treatment in SAIS owing to causing no adverse events. | Subacromial Impingement Syndrome (SAIS) | Randomized | Arch Rheumatol. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31598597/ | 10.5606/ArchRheumatol.2019.7225 | 9.1 | ||
| Efficacy of Platelet-Rich Plasma for the Treatment of Interstitial Supraspinatus Tears: A Double-Blinded, Randomized Controlled Trial. | Schwitzguebel AJ, et al. | Saline | 80 | 12 mths |  | PRP injections within interstitial supraspinatus tears did not improve tendon healing or clinical scores compared with saline injections and were associated with more adverse events. | Rotator Cuff Tear | Randomized, Double-Blind | Am J Sports Med. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31161947/ | 10.1177/0363546519851097 | 9.10 | ||
| Sodium Hyaluronate and Platelet-Rich Plasma for Partial-Thickness Rotator Cuff Tears. | Cai YU, et al. | Saline, HA, HA+PRP | 200 (184 fin.) | 12 mths | | Our study provided evidence of the efficacy of PRP injection in the healing of small to medium PTRCT. Moreover, the combined injection of SH and PRP yielded a better clinical outcome than SH or PRP alone. | Rotator Cuff Tear | Randomized | Med Sci Sports Exerc. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30199423/ | 10.1249/MSS.0000000000001781 | 9.11 | ||
| Platelet-rich plasma injection in the treatment of frozen shoulder: A randomized controlled trial with 6-month follow-up | Lin J. | Anesthetic | 60 | 6 mths | | PRP and procaine were effective in treating frozen shoulder. PRP was more effective and had a more prolonged efficiency than the procaine control. Nevertheless, the definite conclusion should come from further large-scale clinical trials. | Adhesive Capsulitis | Randomized | Int J Clin Pharmacol Ther. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29932415/ | 10.5414/CP203262 | 9.12 | ||
| Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled Trial | Nejati P, et al. | Physical Therapy | 62 | 6 mths | ' | Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective. | Subacromial Impingement Syndrome (SAIS) | Randomized | Orthop J Sports Med. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28567426/ | 10.1177/2325967117702366 | 9.13 | ||
| Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears | Shams A, et al. | Corticosteroid | 40 | 6 mths | | PRP injections showed earlier better results as compared to corticosteroid injections, although statistically significant better results after 6 months could not be found. Therefore, subacromial RPP injection could be considered as a good alternative to corticosteroid injection, especially in patients with a contraindication to corticosteroid administration. | Rotator Cuff Tear | Randomized | Eur J Orthop Surg Traumatol. | 2016 | https://pubmed.ncbi.nlm.nih.gov/27544678/ | 10.1007/s00590-016-1826-3 | 9.2 | ||
| Platelet-Rich Plasma Treatment With Physical Therapy in Chronic Partial Supraspinatus Tears | Ilhanli I, et al. | Physical Therapy | 70 | 12 mths | | When we compared with PT, PRP seemed to be a well-tolerated application which showed promising results in patients with chronic partial supraspinatus tears. | Rotator Cuff Tear | Randomized | Iran Red Crescent Med J. | 2015 | https://pubmed.ncbi.nlm.nih.gov/26473076/ | 10.5812/ircmj.23732 | 9.14 | ||
| Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. | Kesikburun S, et al. | Saline | 40 | 1 yr | | At 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program. | Rotator Cuff Tear | Randomized, Double-Blind | Am J Sports Med. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23893418/ | 10.1177/0363546513496542 | 9.9 | ||
| Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial. | Rha DW, et al. | Dry Needling | 39 | 6 mths | | Autologous platelet-rich plasma injections lead to a progressive reduction in the pain and disability when compared to dry needling. This benefit is certainly still present at six months after treatment. These findings suggest that treatment with platelet-rich plasma injections is safe and useful for rotator cuff disease. | Rotator Cuff Disease | Randomized, Double-Blind | Clin Rehabil. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23035005/ | 10.1177/0269215512448388 | 10.1 |
Epicondylitis / Tennis Elbow
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Is Ultrasound (US)-Guided Platelet-Rich Plasma Injection More Efficacious as a Treatment Modality for Lateral Elbow Tendinopathy Than US-Guided Steroid Injection?: A Prospective Triple-Blinded Study with Midterm Follow-up. | Kamble P, et al. | Corticosteroid | 64 | 2 year | | Corticosteroid injections alleviated symptoms of LET over short-term follow-up providing quicker symptomatic relief; however, the effect faded off over the long term. PRP injections provided a more gradual but sustained improvement over the long-term follow-up, indicating the biological healing potential of PRP. | Epicondylitis | Randomized, Triple-Blind | Clin Orthop Surg. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37274509/ | 10.4055/cios22128 | 12.10 | ||
| Management of Lateral Epicondylitis: A Prospective Comparative Study Comparing the Local Infiltrations of Leucocyte Enriched Platelet-Rich Plasma (L-aPRP), Glucocorticoid and Normal Saline | Arora KK, et al. | Corticosteroid, Saline | 60 | 12 wks | | PRP leads to superior healing with long-term therapeutic advantages compared to corticosteroids though it takes a little longer to have its effect. | Epicondylitis | Randomized | Malays Orthop J. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35519524/ | 10.5704/MOJ.2203.009 | 12.11 | ||
| Comparison of platelet-rich plasma and extracorporeal shock wave therapy in patients with chronic lateral epicondylitis: A prospective, randomized-controlled study. | Şahbaz T, et al. | ESW | 74 | 6 mths | | In the treatment of chronic LE, PRP combined with exercise seems to be superior to exercise or ESWT in terms of pain and functionality in chronic LE patients. | Epicondylitis | Randomized | Turk J Phys Med Rehabil. | 2021 | https://pubmed.ncbi.nlm.nih.gov/35141489/ | 10.5606/tftrd.2021.6377 | 13.3 | ||
| Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial | Martin JI, et al. | Lidocaine | 71 | 12 mths | | PRP results in similar improvements to those obtained with lidocaine. Selecting patients according to their pretreatment status can improve treatment efficacy. | Epicondylitis | Randomized, Double-Blind | J Orthop Surg Res. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31014382/ | 10.1002/jor.23714 | 12.1 | ||
| Relationship of cytokine levels and clinical effect on platelet-rich plasma-treated lateral epicondylitis | Lim W, et al. | Physical Therapy | 156 | 24 wks | | At 24 weeks, all pain and functional variables, including VAS score, Mayo Clinic performance scores, and MRI grade, improved significantly in group 1 (p < 0.05). PDGF-AB, PDGF-BB, and TGF-β levels were more significantly increased in PRP than in whole blood. TGF-β level significantly correlated with Mayo Clinic performance score and MRI grade improvement. Thus, TGF-β level in PRP is considered to play a pivotal role in tendon healing. These results may contribute to identifying the best protocol for PRP application in tendinopathies. | Epicondylitis | Randomized | J Orthop Res. | 2018 | https://pubmed.ncbi.nlm.nih.gov/28851099/ | 10.1186/s13018-019-1153-6 | 12.2 | ||
| Autologous Platelet-rich Plasma versus Corticosteroid in the Management of Elbow Epicondylitis: A Randomized Study. | Varshney A, et al. | Corticosteroid | 83 | 6 mths | | Treatment of patients with epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection. | Epicondylitis | Randomized | Int J Appl Basic Med Res. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28584745/ | 10.4103/2229-516X.205808 | 12.4 | ||
| Arthroscopic Debridement Versus Platelet-Rich Plasma Injection: A Prospective, Randomized, Comparative Study of Chronic Lateral Epicondylitis With a Nearly 2-Year Follow-Up | Merolla G, et al. | Debridement | 101 | 2 yrs | ' | The present findings suggest that (1) PRP injections and arthroscopic extensor carpi radialis brevis release are both effective in the short and medium term; (2) PRP patients experienced a significant worsening of pain at 2 years; (3) arthroscopic release ensured better long-term outcomes in terms of pain relief and grip strength recovery; and (4) both procedures were safe and well accepted by patients. | Epicondylitis | Randomized | Arthroscopy. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28433443/ | 10.1016/j.arthro.2017.02.009 | 12.12 | ||
| Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial. | Palacio EP, et al. | Neocaine, Glucocorticoid | 60 | 180 days | | At a significance level of 5%, there was no evidence that one treatment was more effective than another, when assessed using the DASH and PRTEE questionnaires. | Epicondylitis | Randomized | Rev Bras Ortop. | 2016 | https://pubmed.ncbi.nlm.nih.gov/26962506/ | 10.1016/j.rboe.2015.03.014 | 12.6 | ||
| [Treatment of elbow epicondylitis with platelet rich plasma versus local corticosteroids] | Martínez-Montiel O, et al. | Corticosteroid | 60 | 6 mths | | The results show that platelet rich plasma provided better results from the perspective of pain control and effect duration. However, the number of applications and the possibility of improving the outcomes if combined with rehabilitation have not yet been determined. | Epicondylitis | Randomized | Acta Ortop Mex. Spanish. | 2015 | https://pubmed.ncbi.nlm.nih.gov/26999966/ | 12.5 | |||
| Comparison of Local Injection of Platelet Rich Plasma and Corticosteroids in the Treatment of Lateral Epicondylitis of Humerus. | Yadav R, et al. | Glucocorticoid | 65 | 3 mths | | PRP and methyl-prenisolone both are effective in the treatment of lateral epicondylitis. However, PRP is a superior treatment option for longer duration efficacy. | Epicondylitis | Randomized | J Clin Diagn Res. | 2015 | https://pubmed.ncbi.nlm.nih.gov/26393174/ | 10.7860/JCDR/2015/14087.6213 | 12.7 | ||
| Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation. | Gautam VK, et al. | Corticosteroid | 30 | 6 mths | | PRP appeared to enable biological healing of the lesion, whereas CS appeared to provide short-term, symptomatic relief but resulted in tendon degeneration. | Epicondylitis | Randomized | J Orthop Surg (Hong Kong). | 2015 | https://pubmed.ncbi.nlm.nih.gov/25920633/ | 10.1177/230949901502300101 | 12.8 | ||
| Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. | Mishra AK, et al. | Physical Therapy | 230 | 24 wks | | No significant differences were found at 12 weeks in this study. At 24 weeks, however, clinically meaningful improvements were found in patients treated with leukocyte-enriched PRP compared with an active control group. | Epicondylitis | Randomized, Double-Blind, Multi-Center | Am J Sports Med. | 2014 | https://pubmed.ncbi.nlm.nih.gov/23825183/ | 10.1177/0363546513494359 | 12.3 | ||
| Is Platelet-rich plasma superior to whole blood in the management of chronic tennis elbow: one year randomized clinical trial. | Raeissadat SA, et al. | Whole Blood | 76 | 12 mths | ' | PRP and autologous whole blood injections are both effective methods to treat chronic lateral epicondylitis and their efficacy persisted during long term follow up. PRP was not superior to AWB in long term follow up. | Epicondylitis | Randomized | BMC Sports Sci Med Rehabil. | 2014 | https://pubmed.ncbi.nlm.nih.gov/24635909/ | 10.1186/2052-1847-6-12 | 13.1 | ||
| Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial. | Krogh TP, et al. | Glucocorticoid, Saline | 60 | 3 mths | | Neither injection of PRP nor glucocorticoid was superior to saline with regard to pain reduction in LE at the primary end point at 3 months. However, injection of glucocorticoid had a short-term pain-reducing effect at 1 month in contrast to the other therapies. Injection of glucocorticoid in LE reduces both color Doppler activity and tendon thickness compared with PRP and saline. | Epicondylitis | Randomized, Double-Blind | Am J Sports Med. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23328738/ | 10.1177/0363546512472975 | 12.13 | ||
| Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. | Gosens T, et al. | Corticosteroid | 100 | 2 year | | Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and increases function significantly, exceeding the effect of corticosteroid injection even after a follow-up of 2 years. Future decisions for application of PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits. | Epicondylitis | Randomized, Double-Blind, Multi-Center | Am J Sports Med. | 2011 | https://pubmed.ncbi.nlm.nih.gov/21422467/ | 10.1177/0363546510397173 | 12.9 | ||
| Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial. | Thanasas C, et al. | Whole Blood | 28 | 6 mths | | Regarding pain reduction, PRP treatment seems to be an effective treatment for chronic lateral elbow epicondylitis and superior to autologous blood in the short term. Defining details of indications, best PRP concentration, number and time of injections, as well as rehabilitation protocol might increase the method's effectiveness. Additionally, the possibility of cost reduction of the method might justify the use of PRP over autologous whole blood for chronic or refractory tennis elbow. | Epicondylitis | Randomized | Am J Sports Med. | 2011 | https://pubmed.ncbi.nlm.nih.gov/21813443/ | 10.1177/0363546511417113 | 13.2 |
Carpal Tunnel Syndrome
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| One-Year Efficacy of Platelet-Rich Plasma for Moderate-to-Severe Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial | Chen SR, et al. | Saline | 26 (52 wrists) | 12 mths | | A single dose of ultrasound-guided perineural PRP injection can provide therapeutic effect for 1 year postinjection. | Carpal Tunnel Syndrome | Randomized, Double-Blind | Arch Phys Med Rehabil. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33548206/ | 10.1016/j.apmr.2020.12.025 | 11.6 | ||
| Platelet-rich plasma in treatment of patients with idiopathic carpal tunnel syndrome | Senna MK, et al. | Corticosteroid | 98 | 3 mths | | Platelet-rich plasma could be effective treatment of mild to moderate idiopathic CTS and superior to corticosteroid in improving pain, function, and distal sensory latency of median nerve. | Carpal Tunnel Syndrome | Randomized | Clin Rheumatol. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31420812/ | 10.1007/s10067-019-04719-7 | 11.1 | ||
| Comparison of perineural platelet-rich plasma and dextrose injections for moderate carpal tunnel syndrome: A prospective randomized, single-blind, head-to-head comparative trial | Shen YP, et al. | Dextrose | 52 | 6 mths | | A single perineural injection of PRP reduced the CSA of the median nerve more effectively than injection of D5W at 3 and 6 months postinjection for patients with moderate CTS. | Carpal Tunnel Syndrome | Randomized, Double-Blind | J Tissue Eng Regen Med. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31368191/ | 10.1002/term.2950 | 11.2 | ||
| Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial | Raeissadat SA, et al. | Wrist Brace | 41 | 10 wks | ' | The findings of this study showed that in a relatively short period of time after treatment, a single injection of platelet-rich plasma in the wrist does not significantly add to the effects of conservative treatment with wrist splints, in regards to the women pain and symptom severity, functional status and electrophysiological parameters. | Carpal Tunnel Syndrome | Randomized | BMC Musculoskelet Disord. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29433485/ | 10.1186/s12891-018-1963-4 | 11.3 | ||
| Platelet-rich plasma ultrasound-guided injection in the treatment of carpal tunnel syndrome: A placebo-controlled clinical study. | Malahias MA, et al. | Saline | 50 | 12 wks | | The findings of this study suggest that a single PRP ultrasound-guided injection has positive effects in patients with CTS. | Carpal Tunnel Syndrome | Randomized | J Tissue Eng Regen Med. | 2018 | https://pubmed.ncbi.nlm.nih.gov/28873284/ | 10.1038/10.1002/term.2566 | 11.5 | ||
| Platelet-rich plasma versus corticosteroid injections for carpal tunnel syndrome. | Uzun H, et al. | Corticosteroid | 40 | 6 mths | | Platelet-rich plasma injections may be considered for the temporary symptomatic relief of mild carpal tunnel syndrome. | Carpal Tunnel Syndrome | J Plast Surg Hand Surg. | 2017 | https://pubmed.ncbi.nlm.nih.gov/27921443/ | 10.1080/2000656X.2016.1260025 | 11.7 | |||
| Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial | Wu YT, et al. | Wrist Brace | 60 | 6 mths | | Our study demonstrates that PRP is a safe modality that effectively relieves pain and improves disability in the patients with CTS. | Carpal Tunnel Syndrome | Randomized | Sci Rep. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28273894/ | 10.1038/s41598-017-00224-6 | 11.4 |
Lumbar Spine
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| "Platelet-Rich Plasma" epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial | Wongjarupong A, et al. | Corticosteroid | 30 | 24 wks | | Noncommercial epidural double-spin PRP yielded superior results to triamcinolone. Due to its efficacy and safety, the procedure is recommended in treating single level lumbar HNP. | Lumbar Herniated Disc | Randomized | BMC Musculoskelet Disord. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37118707/ | 10.1186/s12891-023-06429-3 | 14.4 | ||
| Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar radiculopathy: A Prospective, Double-Blind Randomized Study | Saraf A, et al. | Corticosteroid | 60 | 6 mths | | Transforaminal injections of PRP and steroid improve short-term (up to 3 months) clinical outcome scores in discogenic lumbar radiculopathy, but clinically meaningful improvements sustaining for 6 months were provided by PRP only. | Lumbar Radiculopathy | Randomized, Double-Blind | Indian J Orthop. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37384009/ | 10.1007/s43465-023-00898-3 | 14.5 | ||
| Effect of autologous platelet-rich plasma (PRP) on low back pain in patients with prolapsed intervertebral disc: A randomised controlled trial | Singh GK, et al. | Corticosteroid | 42 | 6 mths | | PRP provided sustained relief from low back pain due to IVDP and can be recommended as a safe and promising alternative to epidural local anaesthetics and steroids. | Lumbar Herniated Disc | Randomized, Double-Blind | Indian J Anaesth. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37250523/ | 10.4103/ija.ija_821_22 | 14.6 | ||
| The role of intra-articular injection of autologous platelet-rich plasma versus corticosteroids in the treatment of synovitis in lumbar facet joint disease | Kotb SY, et al. | Corticosteroid | 30 | 3 mths | | Both PRP and CS injections were effective in improving MRI-detected FJ synovitis while concurrently improving all examined parameters at follow-up after 3 months. However, PRP promoted better improvement in MRI-detected synovitis grade, suggesting that it may be a better treatment option for longer duration efficacy. | Lumbar Facet Joint Synd. | Randomized | Saudi Med J. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36379530/ | 10.15537/smj.2022.43.11.20220449 | 14.2 | ||
| Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study | Xu Z, et al. | Corticosteroid | 124 | 12 mths | | The results showed similar outcome for both transforaminal injections using PRP and steroid in the treatment of lumbar disc herniation, suggesting the possible application of PRP injection as a safer alternative. | Lumbar Herniated Disc | Randomized | Neural Plast. | 2021 | https://pubmed.ncbi.nlm.nih.gov/37250523/ | 10.4103/ija.ija_821_22 | 14.7 | ||
| A Randomized Double-Blind Controlled Pilot Study Comparing Leucocyte-Rich Platelet-Rich Plasma and Corticosteroid in Caudal Epidural Injection for Complex Chronic Degenerative Spinal Pain | Ruiz-Lopez R, Tsai YC. | Corticosteroid | 50 | 6 mths | | Both autologous LR-PRP and corticosteroid for caudal epidural injections under fluoroscopic guidance are equally safe and therapeutically effective in patients with complex chronic lumbar spinal pain. However, LR-PRP is superior to corticosteroid for a longer pain-relieving effect and improvement in quality of life. | Lumbar Spinal Pain | Randomized, Double-Blind | Pain Pract. | 2020 | https://pubmed.ncbi.nlm.nih.gov/32255266/ | 10.1111/papr.12893 | 14.8 | ||
| A Prospective Study Comparing Platelet-Rich Plasma and Local Anesthetic (LA)/Corticosteroid in Intra-Articular Injection for the Treatment of Lumbar Facet Joint Syndrome | Wu J, et al. | Corticosteroid | 46 | 6 mths | | Both autologous PRP and LA/corticosteroid for intra-articular injection are effective, easy, and safe enough in the treatment of lumbar facet joint syndrome. However, autologous PRP is a superior treatment option for longer duration efficacy. | Lumbar Facet Joint Synd. | Randomized | Pain Pract. | 2017 | https://pubmed.ncbi.nlm.nih.gov/27989008/ | 10.1111/papr.12544 | 14.3 | ||
| Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study | Tuakli-Wosornu YA, et al. | Contrast Agent/Discography | 47 | 1 yr | | Participants who received intradiskal PRP showed significant improvements in FRI, NRS Best Pain, and NASS patient satisfaction scores over 8 weeks compared with controls. Those who received PRP maintained significant improvements in FRI scores through at least 1 year of follow-up. Although these results are promising, further studies are needed to define the subset of participants most likely to respond to biologic intradiskal treatment and the ideal cellular characteristics of the intradiskal PRP injectate. | Lumbar Discogenic Pain | Randomized, Double-Blind | PM R. | 2016 | https://pubmed.ncbi.nlm.nih.gov/26314234/ | 10.1016/j.pmrj.2015.08.010 | 14.1 |
Osteoarthritis of the Hip
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: a randomized clinical trial. | Nouri F, et al. | HA, PRP+HA | 105 | 6 mths | | Although all 3 interventions were associated with improvement of pain and function in patients with hip OA, the therapeutic effects of PRP and PRP + HA injections lasted longer (6 months), and the effects of these two interventions on patients' performance, disability, and the activities of daily living (ADL) were superior to HA in the long run. Moreover, the addition of HA to PRP was not associated with a significant increase in the therapeutic results. | Osteoarthritis (Hip) | Randomized | BMC Musculoskelet Disord. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36096771/ | 10.1186/s12891-022-05787-8 | 6.4 | |||
| Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis | Di Sante L, et al. | HA | 43 | 16 wks | | Intra-articular PRP had an immediate effect on pain that was not maintained at longer term follow-up when, on the contrary, the effects of intra-articular HA were evident. | Osteoarthritis (Hip) | Randomized | Med Ultrason. | 2016 | https://pubmed.ncbi.nlm.nih.gov/27981279/ | 10.11152/mu-874 | 6.1 | |||
| Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study | Dallari D, et al. | HA, PRP+HA | 111 | 12 mths | | Results indicated that intra-articular PRP injections offer a significant clinical improvement in patients with hip OA without relevant side effects. The benefit was significantly more stable up to 12 months as compared with the other tested treatments. The addition of PRP+HA did not lead to a significant improvement in pain symptoms. | Osteoarthritis (Hip) | Randomized | Am J Sports Med. | 2016 | https://pubmed.ncbi.nlm.nih.gov/26797697/ | 10.1177/0363546515620383 | 6.2 | |||
| Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. | Battaglia M, et al. | HA | 100 | 12 mths | | Intra-articular injections of PRP are efficacious in terms of functional improvement and pain reduction but are not superior to HA in patients with symptomatic hip OA at 12-month follow-up. | Osteoarthritis (Hip) | Randomized | Orthopedics. | 2013 | https://pubmed.ncbi.nlm.nih.gov/24579221/ | 10.3928/01477447-20131120-13 | 6.3 |
Sacroiliac Joint (SIJ) Pain
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intra-Articular Platelet Rich Plasma vs Corticosteroid Injections for Sacroiliac Joint Pain: A Double-Blinded, Randomized Clinical Trial | Chen AS, et al. | Corticosteroid | 26 | 3 mths | | Although both groups showed improvements in pain and function, the steroid group had significantly greater response and significantly more responders than did the platelet-rich plasma group. | Sacroiliac Joint (SIJ) Pain | Randomized, Double-Blind | Pain Med. | 2022 | https://pubmed.ncbi.nlm.nih.gov/34850180/ | 10.1093/pm/pnab332 | 15.2 | ||
| Steroid vs. Platelet-Rich Plasma in Ultrasound-Guided Sacroiliac Joint Injection for Chronic Low Back Pain | Singla V, et al. | Glucocorticoid | 40 | 3 mths | | The intra-articular PRP injection is an effective treatment modality in low back pain involving SIJ. | Sacroiliac Joint (SIJ) Pain | Randomized | Pain Pract. | 2017 | https://pubmed.ncbi.nlm.nih.gov/27677100/ | 10.1111/papr.12526 | 15.1 |
Osteoarthritis of the Knee
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effects of platelet-rich plasma on subchondral bone marrow edema and biomarkers in synovial fluid of knee osteoarthritis | Lin E, et al. | HA | 81 | 12 mths | | Intra-articular injection of PRP can significantly reduce the subchondral BME and the level of biomarkers in synovial fluid of the symptomatic knee osteoarthritis. | Osteoarthritis (Knee) | Randomized | Knee. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37001332/ | 10.1016/j.knee.2023.03.002 | 1.19 | ||||
| Clinical and Biochemical Correlation of Intra-articular Platelet-Rich Plasma and Corticosteroid Using Serum Matrix Metalloproteinase 3 (MMP-3) Levels in Osteoarthritis of Knee. | Arora V, et al. | Corticosteroid | 96 (87 fin.) | 9 mths | | PRP is unquestionably a better option than CS in OA of the knee based on boosting functional activity, lowering stiffness, and reducing pain, all three of which are denoted by the WOMAC and VAS scores as the effect of PRP lasts longer than CS injections for the aforesaid issues. We could not find any significant change in levels of MMP3 post PRP and CS injections, which signifies that these two modalities do not have any effect in either preventing cartilage degeneration or promoting cartilage regeneration. Our findings have shown that PRP injections are safe, minimally invasive, and effective treatment modalities for OA knee. | Osteoarthritis (Knee) | Randomized | Cureus. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37388595/ | 10.7759/cureus.39625 | 2.11 | ||||
| A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis. | Tschopp M, et al. | Glucocorticoid, HA | 95 (120 knees) | 6 mths | | There is no evidence that knee injections with glucocorticoid, PRP, or hyaluronic acid have superior short- or long-term effects in patients with low pain level at baseline and early- to middle-stage knee OA when compared with placebo. | Osteoarthritis (Knee) | Randomized, Double-Blind, Placebo-Controlled | Invest Radiol. | 2023 | https://pubmed.ncbi.nlm.nih.gov/36728848/ | 10.1097/RLI.0000000000000942 | 2.12 | ||||
| Is the Combination of Platelet-Rich Plasma and Hyaluronic Acid the Best Injective Treatment for Grade II-III Knee Osteoarthritis? A Prospective Study. | Ciapini G, et al. | HA, HA+PRP | 60 | 6 mths | | The combination of platelet-rich plasma and hyaluronic acid can be effective in the treatment of grade II-III knee osteoarthritis in a short-to-mid-term scenario. It represents an innovative and valuable alternative to the administration of its two components alone. | Osteoarthritis (Knee) | Randomized | Adv Orthop. | 2023 | https://pubmed.ncbi.nlm.nih.gov/36938102/ | 10.1155/2023/1868943 | 2.15 | ||||
| Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial | Gobbi A, et al. | Adipose Tissue | 50 (80 knees) | 24 mths | | Autologous microfragmented adipose tissue did not show significant superior clinical improvement compared with three LP-PRP combined with HA injections in terms of functional improvement at different follow-up points. Both procedures were safe with no major complications reporting good results at mid-term follow-up, improving knee function, pain, and quality of live regardless of age and gender. | Osteoarthritis (Knee) | Randomized | Eur J Orthop Surg Traumatol. | 2023 | https://pubmed.ncbi.nlm.nih.gov/35997833/ | 10.1007/s00590-022-03356-2 | 3.5 | ||||
| Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis | Küçükakkaş O, et al. | HA | 40 | 6 mths | | […] both treatment approaches had significant positive effects on pain, stiffness, and function and no superiority was observed over each other. | Osteoarthritis (Knee) | Randomized | Acta Orthop Belg. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36800668/ | 10.52628/88.4.10243 | 1.20 | ||||
| Comparison of clinical outcome, cartilage turnover, and inflammatory activity following either intra-articular or a combination of intra-articular with intra-osseous platelet-rich plasma injections in osteoarthritis knee: A randomized, clinical trial. | Barman A, et al. | Saline | 96 | 12 wks | | Significant clinical improvements were noticed following IA-PRP and IA-IO-PRP injections compared to IA-NS injections. Both PRP groups reported a significant reduction in ESR, CRP, and CTX-II levels at 12 weeks. Persons in the IA+IO-PRP group reported significant changes in u-NTX-I level and knee-USG findings. | Osteoarthritis (Knee) | Randomized, Single-Blind | Injury. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36414504/ | 10.1016/j.injury.2022.11.036 | 2.6 | ||||
| Serial Platelet-Rich Plasma Intra-articular Injections in Kellgren and Lawrence Grade IV Knee Joint Osteoarthritis: A Prospective Blinded Placebo-Controlled Interventional Study. | Saraf A, et al. | Saline | 90 (84 fin.) | 6 mths | | Serial Intra-articular Injections of autologous PRP mildly improve short-term subjective pain and knee function scores in patients of Grade IV KOA without any major complications. | Osteoarthritis (Knee) | Randomized | Indian J Orthop. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36187584/ | 10.1007/s43465-022-00730-4 | 2.7 | ||||
| Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis. | Pretorius J, et al. | Corticosteroid | 29 (58 knees) | 6 mths | | Both corticosteroids and PRP interventions are effective in improving pain, stiffness, and function in patients with bilateral knee osteoarthritis up to six months with no statistically significant difference between the two. | Osteoarthritis (Knee) | Randomized, Double-Blind | Cureus. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36324362/ | 10.7759/cureus.29744 | 2.13 | ||||
| Assessment of the effectiveness and satisfaction of platelet-rich plasma compared with hyaluronic acid in knee osteoarthritis at minimum 7-year follow-up: A post hoc analysis of a randomized controlled trial. | Wang Z, et al. | HA | 100 (85 fin.) | 79 mths | | PRP was more effective than HA in survival and re-intervention rates, VAS, and WOMAC, although there were no significant differences in the imaging evaluation between the two groups. Furthermore, patients treated with PRP were associated with higher satisfaction compared with HA. | Osteoarthritis (Knee) | Randomized | Front Bioeng Biotechnol. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36507262/ | 10.3389/fbioe.2022.1062371 | 2.16 | ||||
| Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial. | Wang YC, et al. | HA | 110 | 6 mths | | This study revealed that both PRP and HA can yield significant improvements in WOMAC scores at 6-month follow-up without any between-group differences at 1-, 3-, and 6-month follow-ups. Thus, both the single-injection regimens of PRP and HA can improve the functional outcomes for treating early-stage knee OA. | Osteoarthritis (Knee) | Randomized, Double-Blind | Medicina (Kaunas). | 2022 | https://pubmed.ncbi.nlm.nih.gov/36013495/ | 10.3390/medicina58081028 | 2.17 | ||||
| Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Randomized Controlled Trial. | Baria M, et al. | Adipose Tissue | 58 | 6 mths | | A single injection of either PRP or MFAT resulted in a clinically meaningful improvement for patients with knee OA at 6 months, with no difference between treatment groups. | Osteoarthritis (Knee) | Randomized | Orthop J Sports Med. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36147791/ | 10.1177/23259671221120678 | 3.4 | ||||
| Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-Year Follow-up. | Zaffagnini S, et al. | Adipose Tissue | 118 | 24 mths | | A single intra-articular injection of MF-AT was not superior to PRP, with comparable low numbers of failures and adverse events and without disease progression. No differences were found in clinical and imaging results between the 2 biological approaches. | Osteoarthritis (Knee) | Randomized | Am J Sports Med. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35984721/ | 10.1177/03635465221115821 | 3.6 | ||||
| A Comparative Study of Osteoarthritis Knee Arthroscopy versus Intra-Articular Platelet Rich Plasma Injection: A Randomised Study. | Singh N, et al. | Arthroscopy | 70 | 9 mths | | This study suggested that both PRP as well as arthroscopy provide a reduction in WOMAC and VAS scores for pain among cases of knee osteoarthritis. Most effective reduction is observed at three months follow-up which thereafter tends to diminish. Of the two modalities, PRP seemed to have an edge over arthroscopic debridement, however, this efficacy was more pronounced for Kellgren-Lawrence Grade 2 as compared to Grade 3. | Osteoarthritis (Knee) | Randomized | Malays Orthop J. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35992984/ | 10.5704/MOJ.2207.004 | 3.9 | ||||
| The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial. | Raeissadat SA, et al. | PRGF, HA, Ozone | 238 | 12 mths | | Ozone injection had rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6 months and at the 6-month follow up, PRP, PRGF and HA were superior to ozone. Only patients in PRP and PRGF groups improved symptoms persisted for 12 months. Therefore, these products could be the preferable choices for long-term management. | Osteoarthritis (Knee) | Randomized | BMC Musculoskelet Disord. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33536010/ | 10.1186/s12891-021-04017-x | 3.10 | ||||
| Clinical Efficacy of Platelet-Rich Plasma Injection and Its Association With Growth Factors in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial As Compared With Hyaluronic Acid | Park YB, et al. | HA | 110 | 6 mths | | PRP had better clinical efficacy than HA. High concentrations of growth factors were observed in patients who scored above the MCID for clinical outcomes in the PRP group. These findings indicate that concentration of growth factors needs to be taken into consideration for future investigations of PRP in knee osteoarthritis. | Osteoarthritis (Knee) | Randomized, Double-Blind | Am J Sports Med. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33523756/ | 10.1177/0363546520986867 | 3.11 | ||||
| [Platelet rich plasma intra-articular and extra-articular injection for the treatment of knee osteoarthritis] | Du W, et al. | HA | 48 | 6 mths | | Intra-articular and extra-articular injection of PRP could relieve pain symptoms and improve function of knee joint with higher safety, although the short-term effect is not significantly different from traditional treatment, its medium-long-term effect is stable. It is a safe and effective method for the treatment of knee osteoarthritis. | Osteoarthritis (Knee) | Randomized | Zhongguo Gu Shang. | 2020 | https://pubmed.ncbi.nlm.nih.gov/32233245/ | 10.12200/j.issn.1003-0034.2020.03.004 | 1.17 | ||||
| Comparison of two platelet rich plasma formulations with viscosupplementation in treatment of moderate grade gonarthrosis: A prospective randomized controlled study | Yaradilmis YU, et al. | HA | 90 | 12 mths | | PRP injections produced superior results than HA. LR-PRP seems to be the most effective treatment modality for moderate gonarthrosis especially in normal weighted men at the 6th decade of age. | Osteoarthritis (Knee) | Randomized | J Orthop. | 2020 | https://pubmed.ncbi.nlm.nih.gov/32071523/ | 10.1016/j.jor.2020.01.041 | 1.18 | ||||
| The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis. | Elik H, et al. | Saline | 60 | 6 mths | | PRP treatment had positive effects on the pain, physical function, and quality of life of patients with knee OA, but it did not increase cartilage thickness. | Osteoarthritis (Knee) | Randomized | J Back Musculoskelet Rehabil. | 2020 | https://pubmed.ncbi.nlm.nih.gov/31127755/ | 10.3233/BMR-181374 | 2.2 | ||||
| MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial) | Raeissadat SA, et al. | Saline | 23 (46 knees) | 8 mths | | In this study, in addition to the effect of PRP on VAS and WOMAC, there was a significant effect on radiologic characteristics (patellofemoral cartilage volume and synovitis). For further evaluation, a longer study with a larger sample size is recommended. | Osteoarthritis (Knee) | Randomized, Double-Blind | J Pain Res. | 2020 | https://pubmed.ncbi.nlm.nih.gov/32021396/ | 10.2147/JPR.S204788 | 2.5 | ||||
| Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study. | Kesiktas FN, et al. | Peptide, HA | 54 | 3 mths | | As a result, pain relief and functional improvement were obtained after the intra-articular HA, peptide, and PRP injections in OA, and decrease in pain was better in the peptide group. | Osteoarthritis (Knee) | Randomized | Clin Rheumatol. | 2020 | https://pubmed.ncbi.nlm.nih.gov/32358661/ | 10.1007/s10067-020-05121-4 | 2.14 | ||||
| Bone Marrow Aspirate Concentrate Is Equivalent to Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis at 1 Year: A Prospective, Randomized Trial. | Anz AW, et al. | BMC | 90 | 12 mths | | Both PRP and BMC were effective in improving patient-reported outcomes in patients with mild to moderate knee OA for at least 12 months; neither treatment provided a superior clinical benefit. Autologous PRP and BMC showed promising clinical potential as therapeutic agents for the treatment of OA, and while PRP has strong clinical evidence to support its efficacy, BMC has limited support. This study did not prove BMC to be superior to PRP, providing guidance to clinicians treating OA. It is possible that the results were affected by patients knowing that there was no control group. | Osteoarthritis (Knee) | Randomized | Orthop J Sports Med. | 2020 | https://pubmed.ncbi.nlm.nih.gov/32118081/ | 10.1177/2325967119900958 | 3.3 | ||||
| Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial | Tavassoli M, et al. | HA | 95 | 12 wks | | PRP is a safe and efficient therapeutic option for treatment of knee osteoarthritis. It was demonstrated to be significantly better than hyaluronic acid. We also found that the efficacy of PRP increases after multiple injections. | Osteoarthritis (Knee) | Randomized | World J Orthop. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31572668/ | 10.5312/wjo.v10.i9.310 | 1.5 | ||||
| The combined use of platelet rich plasma and hyaluronic acid: prospective results for the treatment of knee osteoarthritis | Rapila R, et al. | HHA | 60 | 12 mths | | Based on our results we can conclude that the combined PRP and HHA treatment is not only a safe and efficacious procedure which can provide functional benefit but is also significantly better than HHA injective therapy alone, as demonstrated by the comparison within our cohort. | Osteoarthritis (Knee) | J Biol Regul Homeost Agents. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31168999/ | 1.6 | ||||||
| Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study | Huang Y, et al. | HA, CS | 120 | 12 mths | | Intra-articular PRP injections into the knee for symptomatic early stages of KOA are a valid treatment option. The clinical efficacy of IA-PRP is comparable to that of the IA-HA and IA-CS forms after 3 months and the long-term efficacy of IA PRP is superior to IA-HA and IA-CS. | Osteoarthritis (Knee) | Randomized | Orthopade. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30623236/ | 10.1007/s00132-018-03659-5 | 1.7 | ||||
| Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial | Lin K-Y, et al. | HA | 53 (87 knees) | 12 mths | | Intra-articular injections of leukocyte-poor PRP can provide clinically significant functional improvement for at least 1 year in patients with mild to moderate osteoarthritis of the knee. | Osteoarthritis (Knee) | Randomized, Double-Blind, Placebo-Controlled | Arthroscopy. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30611335/ | 10.1016/j.arthro.2018.06.035 | 1.8 | ||||
| Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial | Di Martino A, et al. | HA | 192 | 24 mths | | Both treatments were effective in improving knee functional status and symptoms over time. PRP did not provide an overall superior clinical improvement compared with HA in terms of either symptomatic-functional improvement at different follow-up points or effect duration. | Osteoarthritis (Knee) | Randomized, Double-Blind | Am J Sports Med. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30545242/ | 10.1177/0363546518814532 | 1.9 | ||||
| Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study. | Simental-Mendia M, | PRP Multi Inject | 35 | 48 wks | | The triple infiltration of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up. | Osteoarthritis (Knee) | Randomized | Acta Reumatol Port. | 2019 | https://pubmed.ncbi.nlm.nih.gov/31243258/ | 3.8 | |||||
| Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritis | Yu W, et al. | HA, HA+PRP | 360 | 52 wks | | PRP and HA combination treatment significantly improved arthralgia, reduced humoral and cellular immune responses and promoted angiogenesis, which improved the patients' histological parameters compared with PRP or HA treatment alone. These results suggested that PRP and HA combination treatment may be a potential treatment option for patients with knee osteoarthritis in the future. | Osteoarthritis (Knee) | Randomized, Double-Blind, Placebo-Controlled | Exp Ther Med. | 2018 | https://pubmed.ncbi.nlm.nih.gov/30186448/ | 10.3892/etm.2018.6412 | 1.10 | ||||
| Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial | Buendia-López D, et al. | HA, NSAID | 98 | 52 wks | | Leukocyte-poor platelet-rich plasma (LP-PRP) injections are better in terms of clinical improvement with respect to HA injections or oral NSAID treatment in knee osteoarthritis patients at the 52-week follow-up. Moreover, a single LP-PRP injection is effective. However, LP-PRP has no influence on cartilage progression. | Osteoarthritis (Knee) | Randomized | J Orthop Traumatol | 2018 | https://pubmed.ncbi.nlm.nih.gov/30128934/ | 10.1186/s10195-018-0501-3 | 1.11 | ||||
| Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis | Ahmad HS, et al. | HA | 89 | 6 mths | | Intra-articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra-articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion. | Osteoarthritis (Knee) | Randomized | Int J Rheum Dis. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29878617/ | 10.1111/1756-185X.13315 | 1.12 | ||||
| Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis | Su K, et al. | HA | 86 | 18 mths | | The combination of intraosseous with intra-articular injections of PRP resulted in a significantly superior clinical outcome, with sustained lower VAS and WOMAC scores and improvement in quality of life within 18 months. | Osteoarthritis (Knee) | Randomized | Clin Rheumatol. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29388085/ | 10.1007/s10067-018-3985-6 | 1.13 | ||||
| Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation | Louis ML, et al. | HA | 54 | 3 mths | | Current results indicated that a single injection of very pure PRP offers a significant clinical improvement in the management of knee osteoarthritis, equivalent to a single HA injection in this patient population. Moreover, a significant correlation between the doses of TGF-β1 and PDGF-AB and the worsening of WOMAC score 3 months after the procedure was found. | Osteoarthritis (Knee) | Randomized, Double-Blind | Arthroscopy. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29366744/ | 10.1016/j.arthro.2017.11.035 | 1.14 | ||||
| Treatment of knee osteoarthritis: platelet-derived growth factors vs. hyaluronic acid. A randomized controlled trial | Lisi C, et al. | HA | 58 | 6 mths | | Activated platelet-rich plasma reduces articular damage as evident at MRI, as soon as six months after treatment; it reduces pain and improves patient's function and overall quality of life. | Osteoarthritis (Knee) | Randomized | Clin Rehabil. | 2018 | https://pubmed.ncbi.nlm.nih.gov/28783969/ | 10.1177/0269215517724193 | 1.15 | ||||
| Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factors | Huang G, et al. | Saline | 366 (350 fin.) | [8 wks] | | In conclusion, treatment with PRP for patients with knee osteoarthritis presented beneficial effects in alleviating joint inflammation, cartilage destruction and bone damage, and repairing joint tissue. These results suggested that PRP may be a potential therapeutic agent for knee osteoarthritis. | Osteoarthritis (Knee) | Randomized, Double-Blind | Exp Ther Med. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29599843/ | 10.3892/etm.2018.5794 | 2.3 | ||||
| Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis | Wu YT, et al. | Saline | 20 (40 knees) | 6 mths | | Platelet-rich plasma treatment significantly improves pain, stiffness, and disability in patients with knee osteoarthritis compared with normal saline treatment. Additional strength training is recommended to enhance muscle strength recovery. | Osteoarthritis (Knee) | Randomized | Am J Phys Med Rehabil. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29210705/ | 10.1097/PHM.0000000000000874 | 2.4 | ||||
| Single-dose intra-articular corticosteroid injection prior to platelet-rich plasma injection resulted in better clinical outcomes in patients with knee osteoarthritis: A pilot study. | Camurcu Y, et al. | Corticosteroid | 115 | 12 mths | | According to our results, IA MP injection prior to PRP injection resulted in significantly better clinical outcomes compared to PRP and MP injections alone in patients who had mild to moderate knee OA. | Osteoarthritis (Knee) | J Back Musculoskelet Rehabil. | 2018 | https://pubmed.ncbi.nlm.nih.gov/29710676/ | 10.3233/BMR-171066 | 2.8 | |||||
| Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial | Görmeli G, et al. | HA | 162 | 6 mths | | The clinical results of this study suggest IA PRP and HA treatment for all stages of knee OA. For patients with early OA, multiple (3) PRP injections are useful in achieving better clinical results. For patients with advanced OA, multiple injections do not significantly improve the results of patients in any group. | Osteoarthritis (Knee) | Randomized, Double-Blind, Placebo-Controlled | Knee Surg Sports Traumatol Arthrosc. | 2017 | https://pubmed.ncbi.nlm.nih.gov/26233594/ | 10.1007/s00167-015-3705-6 | 1.2 | ||||
| Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis | Cole BJ, et al. | HA | 111 | 12 mths | | We found no difference between HA and PRP at any time point in the primary outcome measure: the patient-reported WOMAC pain score. Significant improvements were seen in other patient-reported outcome measures, with results favoring PRP over HA. Preceding a significant difference in subjective outcomes favoring PRP, there was a trend toward a decrease in 2 proinflammatory cytokines, which suggest that the anti-inflammatory properties of PRP may contribute to an improvement of symptoms. | Osteoarthritis (Knee) | Randomized, Double-Blind | Am J Sports Med. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28146403/ | 10.1177/0363546516665809 | 1.16 | ||||
| Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial | Joshi Jubert N, et al. | Saline | 75 | 6 mths | | A single PRP intra-articular injection is effective for relieving pain and improving activities of daily living and quality of life in late-stage knee OA. For patients with late-stage knee OA who are 67 years or older, 1 intra-articular injection of PRP has similar results to 1 shot of corticosteroid. | Osteoarthritis (Knee) | Randomized, Double-Blind | Orthop J Sports Med. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28255569/ | 10.1177/2325967116689386 | 2.1 | ||||
| Comparison of Efficiency Between Corticosteroid and Platelet Rich Plasma Injection Therapies in Patients With Knee Osteoarthritis | Uslu Güvendi E, et al. | Corticosteroid | 50 | 6 mths | | Our findings revealed that PRP is a safe treatment option and efficient in osteoarthritis symptom control up to six months after application. Treatment response obtained with corticosteroid injection has a shorter duration than PRP treatment. | Osteoarthritis (Knee) | Randomized | Arch Rheumatol. | 2017 | https://pubmed.ncbi.nlm.nih.gov/30632533/ | 10.5606/ArchRheumatol.2018.6608 | 2.9 | ||||
| Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial. | Joshi Jubert N, et al. | Corticosteroid | 75 | 6 mths | | A single PRP intra-articular injection is effective for relieving pain and improving activities of daily living and quality of life in late-stage knee OA. For patients with late-stage knee OA who are 67 years or older, 1 intra-articular injection of PRP has similar results to 1 shot of corticosteroid. | Osteoarthritis (Knee) | Randomized, Double-Blind | Orthop J Sports Med. | 2017 | https://pubmed.ncbi.nlm.nih.gov/28255569/ | 10.1177/2325967116689386 | 2.10 | ||||
| Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options | Duymus TM, et al. | HA, Ozone | 102 | 12 mths | | In the treatment of mild-moderate knee OA, PRP was more successful than HA and ozone injections, as the application alone was sufficient to provide at least 12 months of pain-free daily living activities. | Osteoarthritis (Knee) | Randomized | Knee Surg Sports Traumatol Arthrosc. | 2017 | https://pubmed.ncbi.nlm.nih.gov/27056686/ | 10.1007/s00167-016-4110-5 | 3.12 | ||||
| Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System | Montañez-Heredia E, et al. | HA | 55 | 6 mths | | PRP was more effective in patients with lower osteoarthritis grades. Both treatments improved pain in knee osteoarthritis patients without statistically significant differences between them. However, PRP injection was proved to improve pain three months after the final infiltration and to be more effective in lower osteoarthritis grades. | Osteoarthritis (Knee) | Randomized | Int J Mol Sci. | 2016 | https://pubmed.ncbi.nlm.nih.gov/27384560/ | 10.3390/ijms17071064 | 1.3 | ||||
| Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee | Lana JF, et al. | HA, HA+PRP | 105 | 12 mths | | The findings of the study support the use of autologous PRP as an effective treatment of mild to moderate knee osteoarthritis. It also shows that the combination of HA and PRP resulted to better outcomes than HA alone up to 1 year and PRP alone up to 3 months. Furthermore, the results suggest that combination of PRP and HA could potentially provide better functional outcomes in the first 30 days after treatment with both PRP and HA alone. | Osteoarthritis (Knee) | Randomized, Multi-Center, Double-Blind | J Stem Cells Regen Med. | 2016 | https://pubmed.ncbi.nlm.nih.gov/28096631/ | 10.46582/jsrm.1202011 | 1.4 | ||||
| Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis. | Simental-Mendía M, et al. | Pharma | 65 | 24 wks | | Treatment with LP-PRP injections resulted in a significantly better clinical outcome than did treatment with acetaminophen, with sustained lower EVA and WOMAC scores and improvement in quality-of-life (higher SF-12 score). Therapy with LP-PRP may positively modify the inflammatory joint environment by counteracting IL-1β action. | Osteoarthritis (Knee) | Randomized | Arch Orthop Trauma Surg. | 2016 | https://pubmed.ncbi.nlm.nih.gov/27506585/ | 10.1007/s00402-016-2545-2 | 3.7 | ||||
| Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study | Paterson KL, et al. | HA | 37 | 12 wks | | This study provides proof-of-concept evidence concerning the feasibility and safety of PA-PRP injections necessary to inform a larger clinical trial in people with knee OA. Our preliminary results also suggest PA-PRP improves self-reported pain, symptoms and lower extremity function, however no between-group differences were found. Photo-activated PRP may provide a safe and effective novel treatment for knee OA. | Osteoarthritis (Knee) | Randomized, Double-Blind | BMC Musculoskelet Disord. | 2016 | https://pubmed.ncbi.nlm.nih.gov/26861957/ | 10.1186/s12891-016-0920-3 | 3.13 | ||||
| Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial) | Raeissadat SA, et al. | HA | 160 | 12 mths | | This study suggests that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment. | Osteoarthritis (Knee) | Randomized | Clin Med Insights Arthritis Musculoskelet Disord. | 2015 | 25624776 | 10.4137/CMAMD.S17894 | 1.1 | ||||
| Treatment of knee osteoarthritis with platelet-rich plasma in comparison with transcutaneous electrical nerve stimulation plus exercise: a randomized clinical trial. | Angoorani H, et al. | Exercise+TENS | 54 | 8 wks | | Intraarticular injection of PRP is an effective, safe method for short-term treatment of patients with knee joint osteoarthritis. | Osteoarthritis (Knee) | Randomized | Med J Islam Repub Iran. | 2015 | https://pubmed.ncbi.nlm.nih.gov/26478881/ | 3.2 | |||||
| Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial. | Rayegani SM, et al. | Exercise | 62 | 6 mths | | This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone. | Osteoarthritis (Knee) | Randomized | Orthop Rev (Pavia). | 2014 | https://pubmed.ncbi.nlm.nih.gov/25317308/ | 10.4081/or.2014.5405 | 3.1 |
Knee (other indications)
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trial | Munde K, et al. | non-PRP | 80 | 6 mths | | These findings demonstrate that PRP can be used as an adjunct therapy for ACL reconstruction, enhancing graft healing and improving patient outcomes. | ACL reconstruction | Randomized | Regen Med. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37491949/ | 10.2217/rme-2023-0108 | 4.2 | |
| Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study. | Kaminski R, et al. | Saline | 72 | > 12 mths | | Our trial indicates that percutaneous meniscal trephination augmented with PRP results in a significant improvement in the rate of chronic meniscal tear healing and this procedure decreases the necessity for arthroscopy in the future (8% vs. 28%, P = 0.032). | Meniscal Lesion | Randomized, Double-Blind | Int J Mol Sci. | 2019 | https://pubmed.ncbi.nlm.nih.gov/30781461/ | 10.3390/ijms20040856 | 4.1 |
Osteoarthritis of the Ankle
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis. | Paget LDA, et al. | Saline | 100 (98 fin.) | 52 wks | | For patients with ankle osteoarthritis, PRP injections did not improve ankle symptoms and function over 52 weeks compared with placebo injections. | Osteoarthritis (Ankle) | Randomized | Med Ultrason. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37417359/ | 10.1177/03635465231182438 | 17.1 |
Fasciitis
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Botulinum toxin A versus platelet rich plasma ultrasound-guided injection in the treatment of plantar fasciitis: A randomised controlled trial | Ruiz-Hernández IM, et al. | Botulinum toxin A | 59 | 1 yr | | PRP and BTX-A injections are effective in patients with plantar fasciitis with BTX-A achieving better short-term pain reduction and PRP better long-term results. | Plantar Fasciitis | Randomized | Foot Ankle Surg. | 2024 | https://pubmed.ncbi.nlm.nih.gov/37949704/ | 10.1016/j.fas.2023.10.004 | 19.7 | |
| Comparative study of local injections of autologous platelet rich plasma versus corticosteroid in management of chronic plantar fasciitis | Sathyendra KG, et al. | Corticosteroid | 70 | 6 mths | | PRP was more effective in chronic plantar fasciitis patients compared to corticosteroids with pain relief coming after first 1st, 3rd and 6th month of the injection. | Plantar Fasciitis | Randomized | J Clin Orthop Trauma. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37520269/ | 10.1016/j.jcot.2023.102225 | 19.6 | |
| Platelet-rich plasma or extracorporeal shockwave therapy for plantar fasciitis | Haddad S, et al. | ESWT | 104 | 24 wks | | Here we showed that PRP injections and ESWT are both beneficial in pain amelioration in patients with chronic plantar fasciitis. We also indicated that PRP injections were associated with better pain reduction results compared to ESWT. | Plantar Fasciitis | Randomized | Int J Burns Trauma. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33824779/ | 19.1 | ||
| Positive Effect of Platelet-Rich Plasma on Pain in Plantar Fasciitis: A Double-Blind Multicenter Randomized Controlled Trial | Peerbooms JC, et al. | Corticosteroid | 115 | 12 mths | | Treatment of patients with chronic plantar fasciitis with PRP seems to reduce pain and increase function more as compared with the effect of corticosteroid injection. | Plantar Fasciitis | Randomized, Double-Blind, Multi-Center | Am J Sports Med. | 2019 | https://pubmed.ncbi.nlm.nih.gov/33824779/ | 10.1177/0363546519877181 | 19.2 | |
| Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled Trial | Uğurlar M, et al. | ESWT, Prolo, Corticosteroid | 158 | 36 mths | ' | The corticosteroid injection was more effective in the first 3 months and extracorporeal shock wave therapy was an effective treatment method in the first 6 months in regard to pain. The corticosteroid injection lost its effectiveness during the follow-up period. The effect of prolotherapy and platelet-rich plasma was seen within 3 to 12 months; however, at the 36-month follow-up point, no differences were found among the 4 treatments. | Plantar Fasciitis | Randomized | J Foot Ankle Surg. | 2018 | https://pubmed.ncbi.nlm.nih.gov/30149850/ | 10.1053/j.jfas.2018.03.017 | 19.4 | |
| Plantar fasciitis: A randomized comparative study of platelet rich plasma and low dose radiation in sportspersons | Gogna P, et al. | Low Dose Radiation | 40 | 6 mths | ' | PRP is as good as LDR in patients with chronic recalcitrant plantar fasciitis not responding to physical therapy. | Plantar Fasciitis | Randomized | Foot (Edinb). | 2016 | https://pubmed.ncbi.nlm.nih.gov/27521483/ | 10.1016/j.foot.2016.08.002 | 19.3 | |
| Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis | Monto RR. | Glucocorticoid | 40 | 24 mths | | PRP was more effective and durable than cortisone injection for the treatment of chronic recalcitrant cases of plantar fasciitis. | Plantar Fasciitis | Randomized | Foot Ankle Int. | 2014 | https://pubmed.ncbi.nlm.nih.gov/24419823/ | 10.1177/1071100713519778 | 19.5 |
Osteoarthritis in Small Joints
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Minimally Invasive Treatment of Trapeziometacarpal Osteoarthritis: Results of a Blinded Randomized Controlled Trial | Winter R, et al. | Adipose Tissue, Saline | 95 | 2 yrs | ' | In addition to pain reduction, the combination of autologous fat and PRP yields a relevant improvement in hand function and a corresponding improvement in quality of life. This treatment seems to be a viable and safe alternative to short-acting glucocorticoids. | Osteoarthritis (Hand) | Randomized | Plast Reconstr Surg. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37039525/ | 10.1097/PRS.0000000000010516 | 5.3 | ||
| Platelet-Rich Plasma versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Randomized Controlled Clinical Trial | Malahias MA, et al. | Corticosteroid | 33 | 12 mths | | After 12 months' follow-up, the IA-PRP treatment has yielded significantly better results in comparison with the corticosteroids, in terms of VAS score (P = 0.015), Q-DASH score (P = 0.025), and patients' satisfaction (P = 0.002). Corticosteroids offer short-term relief of symptoms, but IA-PRP might achieve a lasting effect of up to 12 months in the treatment of early to moderate symptomatic TMJ arthritis. | Osteoarthritis (Hand) | Randomized | Cartilage. | 2018 | https://pubmed.ncbi.nlm.nih.gov/30343590/ | 10.1177/1947603518805230 | 5.1 |
Tendinopathies
| Publication | Author | Pub. Year | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pubmed | DOI | ID-No | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Platelet-Rich Plasma for Patellar Tendinopathy: A Randomized Controlled Trial of Leukocyte-Rich PRP or Leukocyte-Poor PRP Versus Saline | Scott A, et al. | 2020 | Saline | 57 | 12 mths | | Combined with an exercise-based rehabilitation program, a single injection of LR-PRP or LP-PRP was no more effective than saline for the improvement of patellar tendinopathy symptoms. | Patellar Tendinopathy | Randomized | Am J Sports Med. | https://pubmed.ncbi.nlm.nih.gov/31038979/ | 10.1177/0363546519837954 | 8.2 | |
| Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial | Dragoo JL, et al. | 2014 | Dry Needling | 23 | 26 wks | | A therapeutic regimen of standardized eccentric exercise and ultrasound-guided leukocyte-rich PRP injection with DN accelerates the recovery from patellar tendinopathy relative to exercise and ultrasound-guided DN alone, but the apparent benefit of PRP dissipates over time. | Patellar Tendinopathy | Randomized, Double-Blind | Am J Sports Med. | https://pubmed.ncbi.nlm.nih.gov/24481828/ | 10.1177/0363546513518416 | 8.3 | |
| Leucocyte-Rich Platelet-Rich Plasma Treatment of Gluteus Medius and Minimus Tendinopathy: A Double-Blind Randomized Controlled Trial With 2-Year Follow-up. | Fitzpatrick J, et al. | 2019 | Corticosteroid | 80 | 2 yrs | | Among patients with chronic gluteal tendinopathy and a length of symptoms >15 months, a single intratendinous LR-PRP injection performed under ultrasound guidance results in greater improvement in pain and function than a single CSI. The improvement after LR-PRP injection is sustained at 2 years, whereas the improvement from a CSI is maximal at 6 weeks and not maintained beyond 24 weeks. | Gluteal Tendinopathy | Randomized, Double-Blind | Am J Sports Med. | https://pubmed.ncbi.nlm.nih.gov/30840831/ | 10.1177/0363546519826969 | 8.1 | |
| Comparison of Clinical and Functional Outcomes after Platelet-Rich Plasma Injection and Corticosteroid Injection for the Treatment of de Quervain's Tenosynovitis | Kumar V, et al. | 2022 | Corticosteroid | 60 | 12 mths | ' | Both the modalities are equally effective in the management of DQTSV remittance. PRP is equally effective as corticosteroid in reducing symptoms of first dorsal compartment stenosing tenosynovitis. PRP may have a lower complication profile, however, this benefit should be weighed against the slight increase in cost and time of PRP preparation and injection. | de Quervain's Tenosynovitis | Randomized | J Wrist Surg. | https://pubmed.ncbi.nlm.nih.gov/36926208/ | 10.1055/s-0042-1760124 | 5.2 | |
| Effect of platelet-rich plasma on healing tissues in acute ruptured Achilles tendon: a human immunohistochemistry study | Alsousou J, et al. | 2015 | Saline | 20 | 6 wks | | This is the first study, to our knowledge, to report the immunohistochemical response of ruptured human Achilles tendon to PRP. The findings reveal that locally applied PRP enhanced the maturity of the healing tendon tissues by promoting better collagen I deposition, decreased cellularity, less vascularity, and higher glycosaminoglycan content when compared with control samples. Further work is required to determine the longer term effects of the use of PRP in musculoskeletal diseases. | Achilles Tendon Rupture | Lancet. (Poster Abstact) | https://pubmed.ncbi.nlm.nih.gov/26312841/ | 10.1016/S0140-6736(15)60334-8 | 16.4 | ||
| Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective Study | Boesen AP, et al. | 2017 | High-Volume Injection, Saline | 57 | 6 mths | | Treatment with HVI or PRP in combination with eccentric training in chronic AT seems more effective in reducing pain, improving activity level, and reducing tendon thickness and intratendinous vascularity than eccentric training alone. HVI may be more effective in improving outcomes of chronic AT than PRP in the short term. | Achilles Tendinopathy | Randomized, Double-Blind | Am J Sports Med. | https://pubmed.ncbi.nlm.nih.gov/28530451/ | 10.1177/0363546517702862 | 16.1 | |
| Ultrasound-Guided Injection Therapy of Achilles Tendinopathy With Platelet-Rich Plasma or Saline: A Randomized, Blinded, Placebo-Controlled Trial | Krogh TP, et al. | 2016 | Saline | 24 | 3 mths | | PRP injection did not result in an improved VISA-A score over a 3-month period in patients with chronic AT compared with placebo. The only secondary outcome demonstrating a statistically significant difference between the groups was change in tendon thickness; this difference indicates that a PRP injection could increase tendon thickness compared with saline injection. The conclusions are limited to the 3 months after treatment owing to the large dropout rate. | Achilles Tendinopathy | Randomized | Am J Sports Med. | https://pubmed.ncbi.nlm.nih.gov/27257167/ | 10.1177/0363546516647958 | 16.2 | |
| One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial | de Jonge S, et al. | 2011 | Saline | 54 | 1 yr | ' | This randomized controlled trial showed no clinical and ultrasonographic superiority of platelet-rich plasma injection over a placebo injection in chronic Achilles tendinopathy at 1 year combined with an eccentric training program. | Achilles Tendinopathy | Randomized, Double-Blind | Am J Sports Med. | https://pubmed.ncbi.nlm.nih.gov/21602565/ | 10.1177/0363546511404877 | 16.3 |
Other Indications
Oral- & Maxillofacial
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Platelet-rich plasma therapy for temporomandibular joint osteoarthritis: A randomized controlled trial | Liu SS, et al. | HA | 70 | 6 mths | | Within the limitations of the study it seems that the application of PRP therapy in TMJ-OA is should be considered whenever possible. | TMJ OA | Randomized | J Craniomaxillofac Surg. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37852892/ | 10.1016/j.jcms.2023.09.014 | 20.14 | |
| Intra-articular injection of hyaluronic acid versus platelet-rich plasma following single puncture arthrocentesis for the management of internal derangement of TMJ: A double-blinded randomised controlled trial | Dasukil S, et al. | HA | 90 | 6 mths | | Within the limitations of the present study, it can be concluded that intra-articular PRP may be preferable over HA whenever appropriate, following single needle arthrocentesis in the treatment of TMJ internal derangement. | TMJ internal derangement | Randomized, Double-Blind | J Craniomaxillofac Surg. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36372680/ | 10.1016/j.jcms.2022.10.002 | 20.3 | |
| Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint Osteoarthritis | Asadpour N, etal. | HA, HA+PRP | 30 | 6 mths | | Combined HA and PRP injection following arthrocentesis is more effective than HA or PRP alone in the management of TMJ-OA. | TMJ OA | Randomized | J Oral Maxillofac Surg. | 2022 | https://pubmed.ncbi.nlm.nih.gov/36372680/ | 10.1016/j.joms.2022.05.002 | 20.4 | |
| Platelet-rich plasma improves esthetic postoperative outcomes of maxillofacial surgical procedures | Menchisheva Y, et al. | Control | 100 | 3 mths | | The use of PRP had a pronounced beneficial therapeutic effect in influencing the esthetic outcomes of surgical interventions. | Plastic and reconstructive surgery | Randomized | Acta Chir Plast. | 2021 | https://pubmed.ncbi.nlm.nih.gov/34814693/ | 10.48095/ccachp2021118 | 20.1 | |
| Effect of platelet-rich plasma in alveolar distraction osteogenesis: a controlled clinical trial | Menezes DJ, et al. | Control | 14 | 105 days | | The addition of platelet-rich plasma had a protective effect on the mucosa around the distractor, which decreased the potential for complications. | Alveolar distraction osteogenesis | Randomized | Br J Oral Maxillofac Surg. | 2016 | https://pubmed.ncbi.nlm.nih.gov/26602586/ | 10.1016/j.bjoms.2015.09.027 | 20.11 | |
| Is Arthrocentesis Plus Platelet-Rich Plasma Superior to Arthrocentesis Alone in the Treatment of Temporomandibular Joint Osteoarthritis? A Randomized Clinical Trial | Cömert Kiliç S, et al. | Joint Aspiration, Aspiration+PRP | 30 (47 joints) | 12 mths | | These findings suggested that arthrocentesis and PRP injections constitute a safe and promising method for the treatment of TMJ-OA that is superior to arthrocentesis alone. | TMJ OA | Randomized | J Oral Maxillofac Surg. | 2015 | https://pubmed.ncbi.nlm.nih.gov/25976690/ | 10.1016/j.joms.2015.02.026 | 20.5 | |
| Platelet-Rich Plasma Injection as an Effective Treatment for Temporomandibular Joint Osteoarthritis | Hegab AF, et al. | HA | 50 | 12 mths | | PRP performed better than HA acid in the treatment of TMJ-OA during long-term follow-up in terms of pain reduction and increased interincisal distance. Future studies will focus on the synergistic actions of HA and PRP in the treatment of TMJ-OA. | TMJ OA | Randomized | J Oral Maxillofac Surg. | 2015 | https://pubmed.ncbi.nlm.nih.gov/25882438/ | 10.1016/j.joms.2015.03.045 | 20.7 | |
| Effect of autologous platelet-rich plasma on bone regeneration in mandibular fractures | Daif ET. | Control | 24 | 6 mths | | It can be concluded that direct application of the PRP along the fracture lines may enhance the bone regeneration in mandibular fractures. | Mandibular fracture | Randomized | Dent Traumatol. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23164343/ | 10.1111/edt.12021 | 20.6 | |
| Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial | Eskan MA, et al. | Allograft | 28 | 4 mths | | These clinical and histologic findings suggest that PRP enhanced bone regeneration and resulted in increased horizontal bone gain and percentage vital bone. | Ridge augmentation | Randomized | J Periodontol. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23895252/ | 10.1902/jop.2013.130260 | 20.2 | |
| Extraction socket preservation graft before implant placement with calcium sulfate hemihydrate and platelet-rich plasma: a clinical and histomorphometric study in humans | Kutkut A, et al. | Collagen resorbable plug dressing | 16 | 3 mths | | MGCSH mixed with PRP showed greater vital bone volume at 3 months with rapid enhancement of bone healing compared to PRP-free collagen resorbable graft. | Dental Implant | Randomized | J Periodontol. | 2012 | https://pubmed.ncbi.nlm.nih.gov/21861639/ | 10.1902/jop.2011.110237 | 20.12 | |
| Sinus grafting using autogenous bone and platelet-rich plasma: histologic outcomes in humans. | Aimetti M, et al. | Autogenous bone | 4 | 6 mths | | Despite similar clinical and radiographic healing patterns, a higher bone-to-implant contact rate was observed on the implants placed in bone and PRP than on those placed in bone only (46.75% +/- 13.6% versus 20.5% +/- 5.57%, respectively). | Sinus augmentation | Randomized | Int J Periodontics Restorative Dent. | 2008 | https://pubmed.ncbi.nlm.nih.gov/19146054/ | 20.8 | ||
| Immediate loading of the grafted maxillary sinus using platelet rich plasma and autogenous bone: a preliminary study with histologic and histomorphometric analysis | Lee CY, et al. | -- | 41 | 8 mths | | The preliminary results of this clinical study indicate that immediate nonfunctional loading using PRP and 50% autogenous bone combined with different substitute graft materials is a predictable protocol in the grafted maxillary sinus as early as 4 months of postgrafting. The high implant survival rate is due to the early formation of large percentages of new vital bone as confirmed by using histologic and histomorphometric analysis. | Dental implant | Randomized | Implant Dent. | 2008 | https://pubmed.ncbi.nlm.nih.gov/18332759/ | 10.1097/ID.0b013e318166ce3c | 20.13 | |
| Platelet-rich plasma activity on maxillary sinus floor augmentation by autologous bone | Consolo U, et al. | Autologous bone | 16 | 7 mths | | Our results seem to indicate a certain regenerative potential of PRP when used with autologous bone. The effect of this enhancement of bone regeneration appeared to be restricted to shorter treatment times. A progressive extinguishment of the PRP effect is recorded after an interval longer than 6-7 months. | Sinus augmentation | Randomized | Clin Oral Implants Res. | 2007 | https://pubmed.ncbi.nlm.nih.gov/17348891/ | 10.1111/j.1600-0501.2006.01330.x | 20.9 | |
| Influence of the application of platelet-enriched plasma in oral mucosal wound healing | Lindeboom JA, et al. | Placebo | 10 | 5 wks | | PRP has a strong stimulant effect on capillary regeneration in wound healing. These effects are mainly noticeable during the early stages of wound healing. | Sinus augmentation | Randomized | Clin Oral Implants Res. | 2007 | https://pubmed.ncbi.nlm.nih.gov/17224034/ | 10.1111/j.1600-0501.2006.01288.x | 20.10 |
Erectile Dysfunction
| Publication | Author | Compared to | No. Patients | Follow-Up | Recommends PRP | Conclusion | Indication | Study Design | Journal | Pub. Year | Pubmed | DOI | ID-No | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial | Masterson TA, et al. | Saline | 61 | 6 mths | ' | The results of our prospective, double-blind, randomized, placebo-controlled clinical trial suggest that 2 injections of intracavernosal platelet-rich plasma separated by 1 month in men with mild to moderate erectile dysfunction is safe, but we found no difference in efficacy between platelet-rich plasma and placebo. | Erectile Dysfunction | Randomized, Double-Blind | J Urol. | 2023 | https://pubmed.ncbi.nlm.nih.gov/37120727/ | 10.1097/JU.0000000000003481 | 18.1 | |
| Is Platelet Rich Plasma Safe and Effective in Treatment of Erectile Dysfunction? Randomized Controlled Study | Shaher H, et al. | Saline | 100 | 6 mths | | PRP is a safe and promising method for the improvement of mild to moderate erectile dysfunction. | Erectile Dysfunction | Randomized | Urology. | 2023 | https://pubmed.ncbi.nlm.nih.gov/36736914/ | 10.1016/j.urology.2023.01.028 | 18.3 | |
| Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial | Poulios E, et al. | Saline | 60 | 6 mths | | PRP intracavernosal injections may be a promising addition to the urologist's armamentarium for the management of ED. Still, further high-quality studies are warranted to corroborate our findings. | Erectile Dysfunction | Randomized, Double-Blind | J Sex Med. | 2021 | https://pubmed.ncbi.nlm.nih.gov/33906807/ | 10.1016/j.jsxm.2021.03.008 | 18.2 |