Marrow Cellution Nucleated Cells

ENHANCE YOUR BIOLOGIC

MARROW CELLUTION

MARROW CELLUTION

Bone Marrow Aspiration & Bone Harvesting Systems

Bone Marrow Aspiration & Bone Harvesting Systems

Maximize Cell Yield & Percutaneous Bone Graft Harvesting

The Marrow Cellution™ System maximizes stem and progenitor cell recovery and minimizes peripheral blood contamination.
Thus, it prevents the subsequent need for additional manipulation procedures such as centrifugation and/or chemical separation which usually require oversight by national regulatory authorities.

A breaktrough aspiration needle offering high concentrations of stem cells in an office setting in less than 10 minutes

INNOVATIVE

Reduces Peripheral Blood Contamination

Closed-end Aspiration Design

Cannula via Sheath Technology

Lateral vs. Distal Collection

EFFICIENT

Never Leaves Sterile Field

Higher CFU-f Counts per mL

Autologous Bone Graft Collection

Additional Steps Not Required

SPECIFIC

Minimally Invasive

Low Volume—High Yield & Quality

Single Puncture—Multiple Aspirations

Regulatory Compliant

Marrow Cellution provides substantial savings in time, effort and expense.

It reduces patient trauma, morbidity and risk of infection.

Bone Marrow Aspiration

The regenerative qualities of bone marrow have been used for decades and are considered the gold standard for stem cell harvesting. However, after the first 1-2 mL of bone marrow aspirate from a traditional needle, the number of total nucleated cells (TNC) in the aspirate drops dramatically due to the lower viscosity of blood and the design of the needle, which operates most optimally for small biopsy volume. After aspirating the first 1-2 mL of bone marrow, peripheral blood will preferentially fill the vacated space, limiting the additional harvest of key stem and progenitor cells.

The Marrow Cellution™ Bone Marrow Aspiration System overcomes this issue. It allows the user to aspirate in a measured and controlled manner over a large geography inside the marrow space, while restricting peripheral blood infiltration.

Traditional Trokar Aspiration

Traditional Trocars produce excess peripheral blood contamination, diminishing cellular yield; thereby requiring additional manipulation steps to achieve the cellular demand necessary for most clinical indications.

Aspiration with Marrow Cellution

Marrow Cellution™ harvests high quality stem and progenitor cells from various levels within the marrow space, while limiting peripheral blood contamination. The system never leaves the sterile field and does not require further manipulation.

Functional design

MC-RAN-11C components

MC-RAN-11C:
Marrow Cellution™ Bone Marrow Aspirate System

The Marrow Cellution™ Bone Marrow Aspiration System is intended for use for aspiration of bone marrow or autologous blood. It allows the user to aspirate in a measured and controlled manner over a large geography inside the marrow space.

Marrow Cellution™ is available in both 11G and 13G and includes an introducer needle, blunt stylet, aspiration cannula and 10mL syringe. The technology is available in multiple lengths and is designed for use in the Iliac Crest, Pedicle, Calcaneous or Tibia.

Every Marrow Cellution™ System includes two important unique features:

  • a closed needle tip to prevent aspiration of excess blood from the entry channel, and
  • a handle with threaded guide for controlled movement of the aspiration cannula within the marrow space.
Closed Tip & Threaded Handle

Bone Marrow Aspiration with Marrow Cellution™

Animation: Bone Marrow Aspiration with the Marrow Cellution™ System

Optimal Syringe Size & Plunger Aspiration Technique
to Maximize Cell Recovery

View the basic Marrow Cellution
process steps overview

Scientific data: CFU-f counts

Marrow Cellution vs. Centrifuge Systems & Traditional Needle

References:
(1) n=5; Scarpone MA, et al. Marrow Cellution Bone Marrow Aspiration System and Related Concentrations of Stem and Progenitor Cells. White Paper 2015.
(2) n=27; Harrell DB, Purita JR. Novel Technology to Increase Concentrations of Stem and Progenitor Cells from Marrow Aspiration. White Paper 2016.
(3) Hegde V, et al. A prospective comparison of three approved systems for autologous bone marrow concentration demonstrated non-equivalency in progenitor cell number and concentration. J Orthop Trauma. 2014 Oct;28(10):591-8.
(4) McLain R, et al. Aspiration of Osteoprogenitor Cells for Augmenting Spinal Fusion: Comparison of Progenitor Cell Concentrations From the Vertebral Body and Iliac Crest. J Bone Joint Surg Am. 2005 Dec; 87(12): 2655–2661.

Bone marrow aspiration & percutaneous cancellous bone harvesting

The Marrow Cellution™ Bone Marrow Aspiration- & Autologous Bone Harvesting System (MC-RAN-8C) allows physicians to combine high quality bone marrow aspirate and percutaneously harvested cancellous bone autograft.

The high cellular composition of Marrow Cellution™ Aspirate combined with percutaneously harvested bone dowel(s) deliver autograft without the associated morbidity.

Bone dowel harvesting with MC-RAN-8C
MC-RAN-8C: Components (package also includes one 10ml syringe)

MC-RAN-8C:
Marrow Cellution™ Bone Marrow Aspiration- & Autologous Bone Harvesting System

Advantages:

  • Graft material with osteoconductive, osteoinductive & osteogenic properties.
  • Minimally invasive technique – using a 8 Gauge Trephine Needle for bone dowel extraction.
  • Graft material may be combined with allogenic, autologous or synthetic bone chips hydrated with high cellular marrow aspirate.
  • Reduces donor site morbidity associated with standard harvesting techniques.

In most countries, the ability to harvest bone graft allows the surgeon to be eligible for additional Diagnostic Related Group (DRG) compensation for autologous bone harvesting and transplantation.

Using the Marrow Cellution™ graft delivery syringe and the Marrow Cellution™ Bone Dowel Harvest device, the clinician can create a combination graft of a vascularized intact bone dowel in the center of the graft surrounded by allogeneic, autologous or synthetic bone chips hydrated with high cellular marrow aspirate.

Higher quality, less quantity, delivered appropriately minimizes host morbidity.

This is potentially a giant step in bone marrow processing. This needle will usher in a new age in bone marrow aspiration.

Dr. Joseph Purita, M.D.Orthopedic Surgeon, Boca Raton/FL

My patients outcomes have improved greatly and quicker since I started using the Marrow Cellution bone marrow needle.

Anne N. Truong, M.D.truong Rehabilitation Center, Fredericksburg/VA, USA

I am always suspicious that when we centrifuge bone marrow aspirate we might be throwing away significant aspects of the regenerative potential of biologic.

Dr. David Harrell, Ph.D.

For the same patient and procedure, the measured number of progenitor cells per cc in the aspirate alone was comparable to the centrifugation concentrate protocol.

Dr. Leonel Liriano, M.D.Prof. for Cardiology and Intensive Care at the Tech. University of Santiago (UTES)

Hands down, the best method is the new Marrow Cellution needle. It’s a game changer. Far easier to use, only one insertion point through the PSIS (rather than multiple entry sites through the ilium), and a MUCH better stem cell yield than the traditional Jamshidi needle approach.

Paul D. Tortland, D.O., FAOASM, RMSK Associate Clinical Professor of Medicine, University of Connecticut School of Medicine

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