A review of bone marrow lesions in the arthritic knee and description of a technique for treatment

Alberto Gobbi, Ignacio Dallo, Rachel M. Frank, Hannah Bradsell, Ivan Saenz, and William Murrel

Journal of Cartilage & Joint Preservation; ePub: 18 Aug 2021. | doi: 10.1016/j.jcjp.2021.100021

New review article from Dr. Alberto Gobbi et al on bone marrow lesions of the arthritic knee currently in press published in the Journal of Cartilage & Joint Preservation:

Introduction: Subchondral bone pathology includes a wide range of pathologies, such as osteoarthritis, spontaneous insufficiency fractures, osteonecrosis, transient bone marrow lesions syndromes, and trauma. They show typical magnetic resonance imaging (MRI) findings termed bone marrow lesions (BMLs). However, the etiology and evolution of BMLs in multiple conditions remains unclear. There is still no gold standard treatment protocol in treating BMLs in the knee, and a variety of treatment modalities have been tested in the hope that they might reduce pain and stop disease progression.

Results: The use of novel biologic techniques to treat BMLs in the knee, such as PRP and Bone Marrow Cells, has yielded promising clinical outcomes.

Conclusions: Future research of BMLs will be mandatory to address the different pathologies better and determining appropriate treatment strategies. There is still a need for high-quality RCTs studies and systematic reviews in the future to enhance further treatment strategy in preventing or treating BMLs of the knee.


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