White blood cell count
The immune system depends on white blood cells to fight infection, but the cells’ role in PRP therapy is unclear. Some experts suspect that white blood cells inhibit tissues’ ability to heal, perhaps promoting inflammation, scar tissue, and damage to nearby tissues.(1)
Clinicians should consider using leukocyte-poor, RBC-free formulations of PRP when administering intra-articularly.(2)
(1) McCarrel TM, Minas T, Fortier LA. Optimization of Leukocyte Concentration in Platelet-Rich Plasma for the Treatment of Tendinopathy.
J Bone Joint Surg Am. 2012 Oct 3;94(19):e143(1-8).
(2) Braun HJ, et al. The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy.
Am J Sports Med. 2014 May;42(5):1204-10.