Marrow Cellution Nucleated Cells




Bone Marrow Aspiration & Bone Harvesting Systems

Bone Marrow Aspiration & Bone Harvesting Systems

Maximize Cell Yield & Percutaneous Bone Graft Harvesting

A breaktrough aspiration needle offering high concentrations of stem cells in an office setting in less than 10 minutes

The Marrow Cellution™ System maximizes stem and progenitor cell recovery and minimizes peripheral blood contamination. Thus, it prevents the subsequent need for additional manipulation procedures such as centrifugation and/or chemical separation which usually require oversight by national regulatory authorities.

Marrow Cellution™ harvests high quality percutaneous bone graft dowels in the same surgical procedure via the same access site, significantly reducing the need for more invasive harvesting procedures that burden the patient and health care provider with more expensive, time intensive, traumatic techniques that increase post-operative pain and morbidity, pharmacologic demand and length of hospitalization.

Overcome Limitations

The regenerative qualities of bone marrow have been used for decades and are considered the gold standard for stem cell harvesting. However, after the first 1-2 mL of bone marrow aspirate from a traditional needle, the number of total nucleated cells (TNC) in the aspirate drops dramatically due to the lower viscosity of blood and the design of the needle, which operates most optimally for small biopsy volume. After aspirating the first 1-2 mL of bone marrow, peripheral blood will preferentially fill the vacated space, limiting the additional harvest of key stem and progenitor cells.

The Marrow Cellution™ Bone Marrow Aspiration System overcomes this issue. It allows the user to aspirate in a measured and controlled manner over a large geography inside the marrow space, while restricting peripheral blood infiltration.

In addition, the Marrow Cellution™ Bone Marrow Aspiration- & Autologous Bone Harvesting System (MC-RAN-8C) allows physicians to combine high quality bone marrow aspirate and percutaneously harvested cancellous bone autograft.

Marrow Cellution™ Bone Marrow Aspirate System




Reduces Peripheral Blood Contamination

Closed-end Aspiration Design

Cannula via Sheath Technology

Lateral vs. Distal Collection


Never Leaves Sterile Field

Higher CFU-f Counts per mL

Autologous Bone Graft Collection

Additional Steps Not Required


Minimally invasive

Low volume—High Yield & Quality

Regulatory Compliant

Single Puncture—Multiple Aspirations

Marrow Cellution™ Bone Marrow Aspirate + Percutaneous Autograft Harvesting System includes an 11G Marrow Cellution™ Bone Marrow Aspiration System along with an 8G Trephine Needle with a specially designed cancellous bone extraction tool.



Functional design

The Marrow Cellution™ System includes two unique features:

  • a closed needle tip to prevent aspiration of excess blood from the entry channel, and
  • a handle with threaded guide for controlled movement of the aspiration cannula within the marrow space.
Marrow Cellution Autologous Bone Graft Harvesting

The MC-RAN-8C Marrow Cellution™ System provides the additional benefit to percutaneously harvest bone graft in the same minimally invasive procedure.

The ability to harvest bone graft percutaneously after the collection of high quality bone marrow, reduces donor site morbidity associated with standard harvesting techniques.

In most countries, the ability to harvest bone graft allows the surgeon to be eligible for additional Diagnostic Related Group (DRG) compensation for autologous bone harvesting and transplantation.

How Marrow Cellution™ works

Animation: Bone Marrow Aspiration with the Marrow Cellution™ System

Traditional Trocar Needle

Marrow Cellution™


Needle Insertion


Standard trocar - needle insertion

Introducer and Cannula Insertion


Marrow Cellution - Aspiration cannula insertion



Standard trocar: aspiration



Marrow Cellution: marrow aspiration



Standard trocar: peripheral blood contamination



Marrow Cellution: marrow aspiration from various levels

Scientific data: CFU-f counts

Marrow Cellution vs. Centrifuge Systems & Traditional Needle

(1) n=5; Scarpone MA, et al. Marrow Cellution Bone Marrow Aspiration System and Related Concentrations of Stem and Progenitor Cells. White Paper 2015.
(2) n=27; Harrell DB, Purita JR. Novel Technology to Increase Concentrations of Stem and Progenitor Cells from Marrow Aspiration. White Paper 2016.
(3) Hegde V, et al. A prospective comparison of three approved systems for autologous bone marrow concentration demonstrated non-equivalency in progenitor cell number and concentration. J Orthop Trauma. 2014 Oct;28(10):591-8.
(4) McLain R, et al. Aspiration of Osteoprogenitor Cells for Augmenting Spinal Fusion: Comparison of Progenitor Cell Concentrations From the Vertebral Body and Iliac Crest. J Bone Joint Surg Am. 2005 Dec; 87(12): 2655–2661.

This is potentially a giant step in bone marrow processing. This needle will usher in a new age in bone marrow aspiration.

Dr. Joseph Purita, M.D.Orthopedic Surgeon, Boca Raton/FL

My patients outcomes have improved greatly and quicker since I started using the Marrow Cellution bone marrow needle.

Anne N. Truong, M.D.truong Rehabilitation Center, Fredericksburg/VA, USA

I am always suspicious that when we centrifuge bone marrow aspirate we might be throwing away significant aspects of the regenerative potential of biologic.

Dr. David Harrell, Ph.D.

For the same patient and procedure, the measured number of progenitor cells per cc in the aspirate alone was comparable to the centrifugation concentrate protocol.

Dr. Leonel Liriano, M.D.Prof. for Cardiology and Intensive Care at the Tech. University of Santiago (UTES)

Hands down, the best method is the new Marrow Cellution needle. It’s a game changer. Far easier to use, only one insertion point through the PSIS (rather than multiple entry sites through the ilium), and a MUCH better stem cell yield than the traditional Jamshidi needle approach.

Paul D. Tortland, D.O., FAOASM, RMSK Associate Clinical Professor of Medicine, University of Connecticut School of Medicine

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